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The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene
Systemic sclerosis (SSc) is a polygenic, autoimmune disorder of unknown etiology, characterized by the excessive accumulation of extracellular matrix (ECM) proteins, vascular alterations, and autoantibodies. The tight skin (Tsk)2/+ mouse model of SSc demonstrates signs similar to SSc including tight...
Autores principales: | Long, Kristen B., Li, Zhenghui, Burgwin, Chelsea M., Choe, Susanna G., Martyanov, Viktor, Sassi-Gaha, Sihem, Earl, Josh, Eutsey, Rory, Ahmed, Azad, Ehrlich, Garth D., Artlett, Carol M., Whitfield, Michael L., Blankenhorn, Elizabeth P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324084/ https://www.ncbi.nlm.nih.gov/pubmed/25330296 http://dx.doi.org/10.1038/jid.2014.455 |
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