Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen

Splenic transitional B-cells (T1 and T2) are selected to avoid self-reactivity and to safeguard against autoimmunity, then differentiate into mature follicular (FO-I and FO-II) and marginal zone (MZ) subsets. Transcriptomic analysis by RNA-seq of the five B-cell subsets revealed T1 cell signature ge...

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Detalles Bibliográficos
Autores principales: Kleiman, Eden, Salyakina, Daria, De Heusch, Magali, Hoek, Kristen L., Llanes, Joan M., Castro, Iris, Wright, Jacqueline A., Clark, Emily S., Dykxhoorn, Derek M., Capobianco, Enrico, Takeda, Akiko, McCormack, Ryan M., Podack, Eckhard R., Renauld, Jean-Christophe, Khan, Wasif N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324157/
https://www.ncbi.nlm.nih.gov/pubmed/25717326
http://dx.doi.org/10.3389/fimmu.2015.00030

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