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Bacteremia with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties

BACKGROUND.  Since Aerococcus sanguinicola was designated as a species in 2001, only a few cases of bacteremia have been reported. The aim with this study was to describe the clinical presentation of A sanguinicola bacteremia and to determine the antibiotic susceptibility and the capacity of the bac...

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Autores principales: Senneby, Erik, Eriksson, Birger, Fagerholm, Erik, Rasmussen, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324188/
https://www.ncbi.nlm.nih.gov/pubmed/25734098
http://dx.doi.org/10.1093/ofid/ofu025
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author Senneby, Erik
Eriksson, Birger
Fagerholm, Erik
Rasmussen, Magnus
author_facet Senneby, Erik
Eriksson, Birger
Fagerholm, Erik
Rasmussen, Magnus
author_sort Senneby, Erik
collection PubMed
description BACKGROUND.  Since Aerococcus sanguinicola was designated as a species in 2001, only a few cases of bacteremia have been reported. The aim with this study was to describe the clinical presentation of A sanguinicola bacteremia and to determine the antibiotic susceptibility and the capacity of the bacteria to form biofilm and to induce platelet aggregation. METHODS.  Isolates of A sanguinicola from blood cultures were retrospectively identified from 2 clinical microbiology laboratories for 2006 to 2012. Species identity was confirmed through sequencing of the 16S rRNA gene. The medical charts of patients were reviewed. The minimum inhibitory concentration (MIC) for relevant antibiotics was determined. Biofilm formation was measured as the amount of crystal violet absorbed. Platelet aggregation was determined by aggregometry. RESULTS.  Eleven cases of A sanguinicola bacteremia were identified. All patients were male and the median age was 82 years (range 67–93). Nine patients fulfilled criteria for severe sepsis, and 2 patients died at hospital. Two patients were diagnosed with infective endocarditis. Most patients had underlying urinary tract diseases or an indwelling urinary tract catheter. Five patients suffered from dementia. None of the patients was treated with immunosuppressive medications. The MIC values of the isolates were in line with previous reports, with low MICs for penicillin, cefotaxime, and vancomycin. All 11 isolates produced biofilms but not all could induce platelet aggregation. CONCLUSIONS.  A sanguinicola can cause severe infections in elderly men with urinary tract abnormalities and the bacteria possess potential virulence mechanisms.
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spelling pubmed-43241882015-03-02 Bacteremia with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties Senneby, Erik Eriksson, Birger Fagerholm, Erik Rasmussen, Magnus Open Forum Infect Dis Major Articles BACKGROUND.  Since Aerococcus sanguinicola was designated as a species in 2001, only a few cases of bacteremia have been reported. The aim with this study was to describe the clinical presentation of A sanguinicola bacteremia and to determine the antibiotic susceptibility and the capacity of the bacteria to form biofilm and to induce platelet aggregation. METHODS.  Isolates of A sanguinicola from blood cultures were retrospectively identified from 2 clinical microbiology laboratories for 2006 to 2012. Species identity was confirmed through sequencing of the 16S rRNA gene. The medical charts of patients were reviewed. The minimum inhibitory concentration (MIC) for relevant antibiotics was determined. Biofilm formation was measured as the amount of crystal violet absorbed. Platelet aggregation was determined by aggregometry. RESULTS.  Eleven cases of A sanguinicola bacteremia were identified. All patients were male and the median age was 82 years (range 67–93). Nine patients fulfilled criteria for severe sepsis, and 2 patients died at hospital. Two patients were diagnosed with infective endocarditis. Most patients had underlying urinary tract diseases or an indwelling urinary tract catheter. Five patients suffered from dementia. None of the patients was treated with immunosuppressive medications. The MIC values of the isolates were in line with previous reports, with low MICs for penicillin, cefotaxime, and vancomycin. All 11 isolates produced biofilms but not all could induce platelet aggregation. CONCLUSIONS.  A sanguinicola can cause severe infections in elderly men with urinary tract abnormalities and the bacteria possess potential virulence mechanisms. Oxford University Press 2014-05-23 /pmc/articles/PMC4324188/ /pubmed/25734098 http://dx.doi.org/10.1093/ofid/ofu025 Text en © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Major Articles
Senneby, Erik
Eriksson, Birger
Fagerholm, Erik
Rasmussen, Magnus
Bacteremia with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties
title Bacteremia with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties
title_full Bacteremia with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties
title_fullStr Bacteremia with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties
title_full_unstemmed Bacteremia with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties
title_short Bacteremia with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties
title_sort bacteremia with aerococcus sanguinicola: case series with characterization of virulence properties
topic Major Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324188/
https://www.ncbi.nlm.nih.gov/pubmed/25734098
http://dx.doi.org/10.1093/ofid/ofu025
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