Point-of-Use Mixing of Influenza H5N1 Vaccine and MF59 Adjuvant for Pandemic Vaccination Preparedness: Antibody Responses and Safety. A Phase 1 Clinical Trial

BACKGROUND:  Avian influenza A/H5N1 has threatened human health for nearly 2 decades. Avian influenza A vaccine without adjuvant is poorly immunogenic. A flexible rapid tactic for mass vaccination will be needed if a pandemic occurs. METHODS:  A multicenter, randomized, blinded phase 1 clinical tria...

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Detalles Bibliográficos
Autores principales: Mulligan, Mark J., Bernstein, David I., Frey, Sharon, Winokur, Patricia, Rouphael, Nadine, Dickey, Michelle, Edupuganti, Srilatha, Spearman, Paul, Anderson, Edwin, Graham, Irene, Noah, Diana L., Mangal, Brian, Kim, Sonnie, Hill, Heather, Whitaker, Jenifer, Emery, William, Beck, Allison, Stephens, Kathy, Hartwell, Brooke, Ogilvie, Melinda, Rimann, Nayoka, Osinski, Eileen, Destefano, Ellen, Gajadhar, Theda, Strudwick, Amanda, Pierce, Karen, Lai, Lilin, Yue, Ling, Wang, Dongli, Ying, Carl, Cline, Amy, Foltz, Tara, Wagner, Nancy, Dull, Geraldine, Pacatte, Thomas, Taggart, Barbara, Johnson, Valerie, Haller, Logan, Looney, Candi, Li, Shixiong, May, Megan, Myers, Bridgette, May, Rachel, Parker, Lawanda, Cochran, Nertaissa, Bowen, Donna, Bell, Michelle, Scoggins, Jeffery, Burns, Angela, Stablein, Claire, Wolff, Mark, Jolles, Bernadette, Leung, Brenda, Lambert, Linda, Shorer, Shy, Buchanan, Wendy, Murray, Suzanne, Chang, Soju, Gorman, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Major Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324215/
https://www.ncbi.nlm.nih.gov/pubmed/25734170
http://dx.doi.org/10.1093/ofid/ofu102

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