Membrane Binding and Subcellular Localization of Retroviral Gag Proteins Are Differentially Regulated by MA Interactions with Phosphatidylinositol-(4,5)-Bisphosphate and RNA

The matrix (MA) domain of HIV-1 mediates proper Gag localization and membrane binding via interaction with a plasma-membrane (PM)-specific acidic phospholipid, phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)]. HIV-1 MA also interacts with RNA, which prevents Gag from binding to membranes contai...

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Detalles Bibliográficos
Autores principales: Inlora, Jingga, Collins, David R., Trubin, Marc E., Chung, Ji Yeon J., Ono, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324246/
https://www.ncbi.nlm.nih.gov/pubmed/25491356
http://dx.doi.org/10.1128/mBio.02202-14

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