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Potent and Selective Small-Molecule Inhibitors of cIAP1/2 Proteins Reveal That the Binding of Smac Mimetics to XIAP BIR3 Is Not Required for Their Effective Induction of Cell Death in Tumor Cells

[Image: see text] Cellular inhibitor of apoptosis protein 1 and 2 (cIAP1/2) and X-linked inhibitor of apoptosis protein (XIAP) are key apoptosis regulators and promising new cancer therapeutic targets. This study describes a set of non-peptide, small-molecule Smac (second mitochondria-derived activa...

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Detalles Bibliográficos
Autores principales:	Sun, Haiying, Lu, Jianfeng, Liu, Liu, Yang, Chao-Yie, Wang, Shaomeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324444/ https://www.ncbi.nlm.nih.gov/pubmed/24521431 http://dx.doi.org/10.1021/cb400889a

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