De Novo Design of Self-Assembling Foldamers That Inhibit Heparin–Protein Interactions

[Image: see text] A series of self-associating foldamers have been designed as heparin reversal agents, as antidotes to prevent bleeding due to this potent antithrombotic agent. The foldamers have a repeating sequence of Lys-Sal, in which Sal is 5-amino-2-methoxy-benzoic acid. These foldamers are de...

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Detalles Bibliográficos
Autores principales: Montalvo, Geronda L., Zhang, Yao, Young, Trevor M., Costanzo, Michael J., Freeman, Katie B., Wang, Jun, Clements, Dylan J., Magavern, Emma, Kavash, Robert W., Scott, Richard W., Liu, Dahui, DeGrado, William F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324449/
https://www.ncbi.nlm.nih.gov/pubmed/24491145
http://dx.doi.org/10.1021/cb500026x

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