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Competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model

Endogenous survivin expression has been related with cancer survival, drug resistance, and metastasis. Therapies targeting survivin have been shown to significantly inhibit tumor growth and recurrence. We found out that a cell-permeable dominant negative survivin (SurR9-C84A, referred to as SR9) com...

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Detalles Bibliográficos
Autores principales:	Roy, Kislay, Kanwar, Rupinder K, Krishnakumar, Subramanian, Cheung, Chun Hei Antonio, Kanwar, Jagat R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324544/ https://www.ncbi.nlm.nih.gov/pubmed/25678789 http://dx.doi.org/10.2147/IJN.S73916

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