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Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator

Many cellular functions necessary for life are tightly regulated by protein allosteric conformational change, and correlated dynamics between protein regions has been found to contribute to the function of proteins not previously considered allosteric. The ability to map and control such dynamic cou...

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Detalles Bibliográficos
Autores principales:	Proctor, Elizabeth A., Kota, Pradeep, Aleksandrov, Andrei A., He, Lihua, Riordan, John R., Dokholyan, Nikolay V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2015
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324596/ https://www.ncbi.nlm.nih.gov/pubmed/25685315 http://dx.doi.org/10.1039/c4sc01320d

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