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Prion Pathogenesis in the Absence of NLRP3/ASC Inflammasomes

The accumulation of the scrapie prion protein PrP(Sc), a misfolded conformer of the cellular prion protein PrP(C), is a crucial feature of prion diseases. In the central nervous system, this process is accompanied by conspicuous microglia activation. The NLRP3 inflammasome is a multi-molecular compl...

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Detalles Bibliográficos
Autores principales:	Nuvolone, Mario, Sorce, Silvia, Schwarz, Petra, Aguzzi, Adriano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324825/ https://www.ncbi.nlm.nih.gov/pubmed/25671600 http://dx.doi.org/10.1371/journal.pone.0117208

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