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High-Affinity Accumulation of a Maytansinoid in Cells via Weak Tubulin Interaction
The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their association with tubulin or microtubules. To identify the mechanisms of this intracellular accumulation and exceptional cytotoxicity of maytan...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324968/ https://www.ncbi.nlm.nih.gov/pubmed/25671541 http://dx.doi.org/10.1371/journal.pone.0117523 |