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Obesity-Hypoventilation Syndrome: Increased Risk of Death over Sleep Apnea Syndrome

AIM: To study whether mortality and cardiovascular morbidity differ in non-invasive ventilation (NIV)-treated patients with severe obesity-hypoventilation syndrome (OHS) as compared with CPAP-treated patients with obstructive sleep apnea syndrome (OSAS), and to identify independent predictors of mor...

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Autores principales: Castro-Añón, Olalla, Pérez de Llano, Luis A., De la Fuente Sánchez, Sandra, Golpe, Rafael, Méndez Marote, Lidia, Castro-Castro, Julián, González Quintela, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324970/
https://www.ncbi.nlm.nih.gov/pubmed/25671545
http://dx.doi.org/10.1371/journal.pone.0117808
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author Castro-Añón, Olalla
Pérez de Llano, Luis A.
De la Fuente Sánchez, Sandra
Golpe, Rafael
Méndez Marote, Lidia
Castro-Castro, Julián
González Quintela, Arturo
author_facet Castro-Añón, Olalla
Pérez de Llano, Luis A.
De la Fuente Sánchez, Sandra
Golpe, Rafael
Méndez Marote, Lidia
Castro-Castro, Julián
González Quintela, Arturo
author_sort Castro-Añón, Olalla
collection PubMed
description AIM: To study whether mortality and cardiovascular morbidity differ in non-invasive ventilation (NIV)-treated patients with severe obesity-hypoventilation syndrome (OHS) as compared with CPAP-treated patients with obstructive sleep apnea syndrome (OSAS), and to identify independent predictors of mortality in OHS. MATERIAL AND METHODS: Two retrospective cohorts of OHS and OSAS were matched 1:2 according to sex, age (±10 year) and length of time since initiation of CPAP/NIV therapy (±6 months). RESULTS: Three hundred and thirty subjects (110 patients with OHS and 220 patients with OSAS) were studied. Mean follow-up time was 7±4 years. The five year mortality rates were 15.5% in OHS cohort and 4.5% in OSAS cohort (p< 0.05). Patients with OHS had a 2-fold increase (OR 2; 95% CI: 1.11–3.60) in the risk of mortality and 1.86 fold (OR 1.86; 95% CI: 1.14–3.04) increased risk of having a cardiovascular event. Diabetes, baseline diurnal SaO(2) < 83%, EPAP < 7 cmH2O after titration and adherence to NIV < 4 hours independently predicted mortality in OHS. CONCLUSION: Mortality of severe OHS is high and substantially worse than that of OSAS. Severe OHS should be considered a systemic disease that encompasses respiratory, metabolic and cardiovascular components that require a multimodal therapeutic approach.
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spelling pubmed-43249702015-02-18 Obesity-Hypoventilation Syndrome: Increased Risk of Death over Sleep Apnea Syndrome Castro-Añón, Olalla Pérez de Llano, Luis A. De la Fuente Sánchez, Sandra Golpe, Rafael Méndez Marote, Lidia Castro-Castro, Julián González Quintela, Arturo PLoS One Research Article AIM: To study whether mortality and cardiovascular morbidity differ in non-invasive ventilation (NIV)-treated patients with severe obesity-hypoventilation syndrome (OHS) as compared with CPAP-treated patients with obstructive sleep apnea syndrome (OSAS), and to identify independent predictors of mortality in OHS. MATERIAL AND METHODS: Two retrospective cohorts of OHS and OSAS were matched 1:2 according to sex, age (±10 year) and length of time since initiation of CPAP/NIV therapy (±6 months). RESULTS: Three hundred and thirty subjects (110 patients with OHS and 220 patients with OSAS) were studied. Mean follow-up time was 7±4 years. The five year mortality rates were 15.5% in OHS cohort and 4.5% in OSAS cohort (p< 0.05). Patients with OHS had a 2-fold increase (OR 2; 95% CI: 1.11–3.60) in the risk of mortality and 1.86 fold (OR 1.86; 95% CI: 1.14–3.04) increased risk of having a cardiovascular event. Diabetes, baseline diurnal SaO(2) < 83%, EPAP < 7 cmH2O after titration and adherence to NIV < 4 hours independently predicted mortality in OHS. CONCLUSION: Mortality of severe OHS is high and substantially worse than that of OSAS. Severe OHS should be considered a systemic disease that encompasses respiratory, metabolic and cardiovascular components that require a multimodal therapeutic approach. Public Library of Science 2015-02-11 /pmc/articles/PMC4324970/ /pubmed/25671545 http://dx.doi.org/10.1371/journal.pone.0117808 Text en © 2015 Castro-Añón et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Castro-Añón, Olalla
Pérez de Llano, Luis A.
De la Fuente Sánchez, Sandra
Golpe, Rafael
Méndez Marote, Lidia
Castro-Castro, Julián
González Quintela, Arturo
Obesity-Hypoventilation Syndrome: Increased Risk of Death over Sleep Apnea Syndrome
title Obesity-Hypoventilation Syndrome: Increased Risk of Death over Sleep Apnea Syndrome
title_full Obesity-Hypoventilation Syndrome: Increased Risk of Death over Sleep Apnea Syndrome
title_fullStr Obesity-Hypoventilation Syndrome: Increased Risk of Death over Sleep Apnea Syndrome
title_full_unstemmed Obesity-Hypoventilation Syndrome: Increased Risk of Death over Sleep Apnea Syndrome
title_short Obesity-Hypoventilation Syndrome: Increased Risk of Death over Sleep Apnea Syndrome
title_sort obesity-hypoventilation syndrome: increased risk of death over sleep apnea syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324970/
https://www.ncbi.nlm.nih.gov/pubmed/25671545
http://dx.doi.org/10.1371/journal.pone.0117808
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