Cargando…

Pregnancy after Treatment for Cervical Cancer Precursor Lesions in a Retrospective Matched Cohort

OBJECTIVE: To determine whether treatments for precancerous cervical lesions were associated with lower pregnancy rates compared to rates in unexposed women and women who had a diagnostic cervical biopsy or colposcopy. DESIGN: Matched, retrospective cohort study. SETTING: Kaiser Permanente Northwest...

Descripción completa

Detalles Bibliográficos
Autores principales: Naleway, Allison L., Weinmann, Sheila, Krishnarajah, Girishanthy, Arondekar, Bhakti, Fernandez, Jovelle, Swamy, Geeta, Myers, Evan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324989/
https://www.ncbi.nlm.nih.gov/pubmed/25671561
http://dx.doi.org/10.1371/journal.pone.0117525
Descripción
Sumario:OBJECTIVE: To determine whether treatments for precancerous cervical lesions were associated with lower pregnancy rates compared to rates in unexposed women and women who had a diagnostic cervical biopsy or colposcopy. DESIGN: Matched, retrospective cohort study. SETTING: Kaiser Permanente Northwest (KPNW), an integrated healthcare delivery system in Oregon and Washington. PATIENTS: Women 14 to 53 years old with KPNW enrollment during the period 1998 through 2009. MAIN OUTCOME MEASURE: Pregnancy after exposure or index date. Pregnancy was defined using a validated algorithm and electronic medical records data. RESULTS: We observed 570 pregnancies following cervical treatment in 4,137 women, 1,533 pregnancies following a diagnostic procedure in 13,767 women, and 7,436 pregnancies in a frequency-matched sample of 81,435 women unexposed to treatment or diagnostic procedures. After adjusting for age and contraceptive use, we observed a higher rate of pregnancies in the treatment group compared to unexposed women (hazard ratio (HR) = 1.42, 95% confidence interval (CI): 1.30–1.55), but no difference in pregnancy rates between the treatment and diagnostic procedure groups (HR = 1.03, 95% CI: 0.93–1.13). CONCLUSIONS: No adverse effects of cervical procedures on subsequent rates of pregnancy were observed in this cohort with up to twelve years of follow-up time.