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Pregnancy after Treatment for Cervical Cancer Precursor Lesions in a Retrospective Matched Cohort

OBJECTIVE: To determine whether treatments for precancerous cervical lesions were associated with lower pregnancy rates compared to rates in unexposed women and women who had a diagnostic cervical biopsy or colposcopy. DESIGN: Matched, retrospective cohort study. SETTING: Kaiser Permanente Northwest...

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Autores principales: Naleway, Allison L., Weinmann, Sheila, Krishnarajah, Girishanthy, Arondekar, Bhakti, Fernandez, Jovelle, Swamy, Geeta, Myers, Evan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324989/
https://www.ncbi.nlm.nih.gov/pubmed/25671561
http://dx.doi.org/10.1371/journal.pone.0117525
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author Naleway, Allison L.
Weinmann, Sheila
Krishnarajah, Girishanthy
Arondekar, Bhakti
Fernandez, Jovelle
Swamy, Geeta
Myers, Evan
author_facet Naleway, Allison L.
Weinmann, Sheila
Krishnarajah, Girishanthy
Arondekar, Bhakti
Fernandez, Jovelle
Swamy, Geeta
Myers, Evan
author_sort Naleway, Allison L.
collection PubMed
description OBJECTIVE: To determine whether treatments for precancerous cervical lesions were associated with lower pregnancy rates compared to rates in unexposed women and women who had a diagnostic cervical biopsy or colposcopy. DESIGN: Matched, retrospective cohort study. SETTING: Kaiser Permanente Northwest (KPNW), an integrated healthcare delivery system in Oregon and Washington. PATIENTS: Women 14 to 53 years old with KPNW enrollment during the period 1998 through 2009. MAIN OUTCOME MEASURE: Pregnancy after exposure or index date. Pregnancy was defined using a validated algorithm and electronic medical records data. RESULTS: We observed 570 pregnancies following cervical treatment in 4,137 women, 1,533 pregnancies following a diagnostic procedure in 13,767 women, and 7,436 pregnancies in a frequency-matched sample of 81,435 women unexposed to treatment or diagnostic procedures. After adjusting for age and contraceptive use, we observed a higher rate of pregnancies in the treatment group compared to unexposed women (hazard ratio (HR) = 1.42, 95% confidence interval (CI): 1.30–1.55), but no difference in pregnancy rates between the treatment and diagnostic procedure groups (HR = 1.03, 95% CI: 0.93–1.13). CONCLUSIONS: No adverse effects of cervical procedures on subsequent rates of pregnancy were observed in this cohort with up to twelve years of follow-up time.
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spelling pubmed-43249892015-02-18 Pregnancy after Treatment for Cervical Cancer Precursor Lesions in a Retrospective Matched Cohort Naleway, Allison L. Weinmann, Sheila Krishnarajah, Girishanthy Arondekar, Bhakti Fernandez, Jovelle Swamy, Geeta Myers, Evan PLoS One Research Article OBJECTIVE: To determine whether treatments for precancerous cervical lesions were associated with lower pregnancy rates compared to rates in unexposed women and women who had a diagnostic cervical biopsy or colposcopy. DESIGN: Matched, retrospective cohort study. SETTING: Kaiser Permanente Northwest (KPNW), an integrated healthcare delivery system in Oregon and Washington. PATIENTS: Women 14 to 53 years old with KPNW enrollment during the period 1998 through 2009. MAIN OUTCOME MEASURE: Pregnancy after exposure or index date. Pregnancy was defined using a validated algorithm and electronic medical records data. RESULTS: We observed 570 pregnancies following cervical treatment in 4,137 women, 1,533 pregnancies following a diagnostic procedure in 13,767 women, and 7,436 pregnancies in a frequency-matched sample of 81,435 women unexposed to treatment or diagnostic procedures. After adjusting for age and contraceptive use, we observed a higher rate of pregnancies in the treatment group compared to unexposed women (hazard ratio (HR) = 1.42, 95% confidence interval (CI): 1.30–1.55), but no difference in pregnancy rates between the treatment and diagnostic procedure groups (HR = 1.03, 95% CI: 0.93–1.13). CONCLUSIONS: No adverse effects of cervical procedures on subsequent rates of pregnancy were observed in this cohort with up to twelve years of follow-up time. Public Library of Science 2015-02-11 /pmc/articles/PMC4324989/ /pubmed/25671561 http://dx.doi.org/10.1371/journal.pone.0117525 Text en © 2015 Naleway et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Naleway, Allison L.
Weinmann, Sheila
Krishnarajah, Girishanthy
Arondekar, Bhakti
Fernandez, Jovelle
Swamy, Geeta
Myers, Evan
Pregnancy after Treatment for Cervical Cancer Precursor Lesions in a Retrospective Matched Cohort
title Pregnancy after Treatment for Cervical Cancer Precursor Lesions in a Retrospective Matched Cohort
title_full Pregnancy after Treatment for Cervical Cancer Precursor Lesions in a Retrospective Matched Cohort
title_fullStr Pregnancy after Treatment for Cervical Cancer Precursor Lesions in a Retrospective Matched Cohort
title_full_unstemmed Pregnancy after Treatment for Cervical Cancer Precursor Lesions in a Retrospective Matched Cohort
title_short Pregnancy after Treatment for Cervical Cancer Precursor Lesions in a Retrospective Matched Cohort
title_sort pregnancy after treatment for cervical cancer precursor lesions in a retrospective matched cohort
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324989/
https://www.ncbi.nlm.nih.gov/pubmed/25671561
http://dx.doi.org/10.1371/journal.pone.0117525
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