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Three Cases of Organized Hematoma of the Maxillary Sinus: Clinical Features and Immunohistological Studies for Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 Expressions

Objectives. Organized hematoma (OH) is a rare, nonneoplastic, hemorrhagic lesion causing mucosal swelling and bone thinning, mainly in the maxillary sinus. We aimed to clarify the clinical presentation and treatment of OH. Methods. Three cases of maxillary sinus OH and a literature review are presen...

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Autores principales: Imayoshi, Shoichiro, Kanazawa, Takeharu, Fukushima, Noriyoshi, Kikuchi, Hisashi, Hasegawa, Masayo, Nagatomo, Takafumi, Nishino, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325202/
https://www.ncbi.nlm.nih.gov/pubmed/25699195
http://dx.doi.org/10.1155/2015/846832
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author Imayoshi, Shoichiro
Kanazawa, Takeharu
Fukushima, Noriyoshi
Kikuchi, Hisashi
Hasegawa, Masayo
Nagatomo, Takafumi
Nishino, Hiroshi
author_facet Imayoshi, Shoichiro
Kanazawa, Takeharu
Fukushima, Noriyoshi
Kikuchi, Hisashi
Hasegawa, Masayo
Nagatomo, Takafumi
Nishino, Hiroshi
author_sort Imayoshi, Shoichiro
collection PubMed
description Objectives. Organized hematoma (OH) is a rare, nonneoplastic, hemorrhagic lesion causing mucosal swelling and bone thinning, mainly in the maxillary sinus. We aimed to clarify the clinical presentation and treatment of OH. Methods. Three cases of maxillary sinus OH and a literature review are presented. Results. Three men aged 16–40 years complained of nasal obstruction, frequent epistaxis, and/or headache. Clinical and radiological examinations revealed a maxillary sinus OH. They were cured in a piecemeal fashion via endoscopic middle meatal antrostomy. Furthermore, vascular endothelial growth factor and its receptor were expressed in the lesion. Conclusions. The pathogenesis of OH is unclear and it presents various histological and imaging findings; however, it is not difficult to rule out malignant tumors. Minimally invasive surgery such as endoscopic sinus surgery can cure it completely. Thus, it is important to determine the diagnosis using CT and MRI and to quickly provide surgical treatment.
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spelling pubmed-43252022015-02-19 Three Cases of Organized Hematoma of the Maxillary Sinus: Clinical Features and Immunohistological Studies for Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 Expressions Imayoshi, Shoichiro Kanazawa, Takeharu Fukushima, Noriyoshi Kikuchi, Hisashi Hasegawa, Masayo Nagatomo, Takafumi Nishino, Hiroshi Case Rep Otolaryngol Case Report Objectives. Organized hematoma (OH) is a rare, nonneoplastic, hemorrhagic lesion causing mucosal swelling and bone thinning, mainly in the maxillary sinus. We aimed to clarify the clinical presentation and treatment of OH. Methods. Three cases of maxillary sinus OH and a literature review are presented. Results. Three men aged 16–40 years complained of nasal obstruction, frequent epistaxis, and/or headache. Clinical and radiological examinations revealed a maxillary sinus OH. They were cured in a piecemeal fashion via endoscopic middle meatal antrostomy. Furthermore, vascular endothelial growth factor and its receptor were expressed in the lesion. Conclusions. The pathogenesis of OH is unclear and it presents various histological and imaging findings; however, it is not difficult to rule out malignant tumors. Minimally invasive surgery such as endoscopic sinus surgery can cure it completely. Thus, it is important to determine the diagnosis using CT and MRI and to quickly provide surgical treatment. Hindawi Publishing Corporation 2015 2015-01-29 /pmc/articles/PMC4325202/ /pubmed/25699195 http://dx.doi.org/10.1155/2015/846832 Text en Copyright © 2015 Shoichiro Imayoshi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Imayoshi, Shoichiro
Kanazawa, Takeharu
Fukushima, Noriyoshi
Kikuchi, Hisashi
Hasegawa, Masayo
Nagatomo, Takafumi
Nishino, Hiroshi
Three Cases of Organized Hematoma of the Maxillary Sinus: Clinical Features and Immunohistological Studies for Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 Expressions
title Three Cases of Organized Hematoma of the Maxillary Sinus: Clinical Features and Immunohistological Studies for Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 Expressions
title_full Three Cases of Organized Hematoma of the Maxillary Sinus: Clinical Features and Immunohistological Studies for Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 Expressions
title_fullStr Three Cases of Organized Hematoma of the Maxillary Sinus: Clinical Features and Immunohistological Studies for Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 Expressions
title_full_unstemmed Three Cases of Organized Hematoma of the Maxillary Sinus: Clinical Features and Immunohistological Studies for Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 Expressions
title_short Three Cases of Organized Hematoma of the Maxillary Sinus: Clinical Features and Immunohistological Studies for Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 Expressions
title_sort three cases of organized hematoma of the maxillary sinus: clinical features and immunohistological studies for vascular endothelial growth factor and vascular endothelial growth factor receptor 2 expressions
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325202/
https://www.ncbi.nlm.nih.gov/pubmed/25699195
http://dx.doi.org/10.1155/2015/846832
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