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Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling

Proper placental development and function are central to the health of both the mother and the fetus during pregnancy. A critical component of healthy placental function is the proper development of its vascular network. Poor vascularization of the placenta can lead to fetal growth restriction, pree...

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Detalles Bibliográficos
Autores principales: Pereira, Robyn D., De Long, Nicole E., Wang, Ruijun C., Yazdi, Fereshteh T., Holloway, Alison C., Raha, Sandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325211/
https://www.ncbi.nlm.nih.gov/pubmed/25705690
http://dx.doi.org/10.1155/2015/814543
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author Pereira, Robyn D.
De Long, Nicole E.
Wang, Ruijun C.
Yazdi, Fereshteh T.
Holloway, Alison C.
Raha, Sandeep
author_facet Pereira, Robyn D.
De Long, Nicole E.
Wang, Ruijun C.
Yazdi, Fereshteh T.
Holloway, Alison C.
Raha, Sandeep
author_sort Pereira, Robyn D.
collection PubMed
description Proper placental development and function are central to the health of both the mother and the fetus during pregnancy. A critical component of healthy placental function is the proper development of its vascular network. Poor vascularization of the placenta can lead to fetal growth restriction, preeclampsia, and in some cases fetal death. Therefore, understanding the mechanisms by which uterine stressors influence the development of the placental vasculature and contribute to placental dysfunction is of central importance to ensuring a healthy pregnancy. In this review we discuss how oxidative stress observed in maternal smoking, maternal obesity, and preeclampsia has been associated with aberrant angiogenesis and placental dysfunction resulting in adverse pregnancy outcomes. We also highlight that oxidative stress can influence the expression of a number of transcription factors important in mediating angiogenesis. Therefore, understanding how oxidative stress affects redox-sensitive transcription factors within the placenta may elucidate potential therapeutic targets for correcting abnormal placental angiogenesis and function.
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spelling pubmed-43252112015-02-22 Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling Pereira, Robyn D. De Long, Nicole E. Wang, Ruijun C. Yazdi, Fereshteh T. Holloway, Alison C. Raha, Sandeep Biomed Res Int Review Article Proper placental development and function are central to the health of both the mother and the fetus during pregnancy. A critical component of healthy placental function is the proper development of its vascular network. Poor vascularization of the placenta can lead to fetal growth restriction, preeclampsia, and in some cases fetal death. Therefore, understanding the mechanisms by which uterine stressors influence the development of the placental vasculature and contribute to placental dysfunction is of central importance to ensuring a healthy pregnancy. In this review we discuss how oxidative stress observed in maternal smoking, maternal obesity, and preeclampsia has been associated with aberrant angiogenesis and placental dysfunction resulting in adverse pregnancy outcomes. We also highlight that oxidative stress can influence the expression of a number of transcription factors important in mediating angiogenesis. Therefore, understanding how oxidative stress affects redox-sensitive transcription factors within the placenta may elucidate potential therapeutic targets for correcting abnormal placental angiogenesis and function. Hindawi Publishing Corporation 2015 2015-01-29 /pmc/articles/PMC4325211/ /pubmed/25705690 http://dx.doi.org/10.1155/2015/814543 Text en Copyright © 2015 Robyn D. Pereira et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pereira, Robyn D.
De Long, Nicole E.
Wang, Ruijun C.
Yazdi, Fereshteh T.
Holloway, Alison C.
Raha, Sandeep
Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling
title Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling
title_full Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling
title_fullStr Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling
title_full_unstemmed Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling
title_short Angiogenesis in the Placenta: The Role of Reactive Oxygen Species Signaling
title_sort angiogenesis in the placenta: the role of reactive oxygen species signaling
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325211/
https://www.ncbi.nlm.nih.gov/pubmed/25705690
http://dx.doi.org/10.1155/2015/814543
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