Anti-HMGB1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma: Attenuated T-Lymphocyte Response and Increased Splenic CD11b(+)Gr-1(+) Myeloid-Derived Suppressor Cells Require HMGB1

Although tissue-derived high mobility group box 1 (HMGB1) is involved in many aspects of inflammation and tissue injury after trauma, its role in trauma-induced immune suppression remains elusive. Using an established mouse model of peripheral tissue trauma, which includes soft tissue and fracture c...

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Detalles Bibliográficos
Autores principales: Ruan, Xiangcai, Darwiche, Sophie S., Cai, Changchun, Scott, Melanie J., Pape, Hans-Christoph, Billiar, Timothy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325468/
https://www.ncbi.nlm.nih.gov/pubmed/25709155
http://dx.doi.org/10.1155/2015/458626

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