Cargando…

An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines

A series of hexahydro-1,6-naphthyridines were synthesized in good yields by the reaction of 3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones with cyanoacetamide in the presence of sodium ethoxide under simple mixing at ambient temperature for 6–10 minutes and were assayed for their acetylcho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Almansour, Abdulrahman I., Suresh Kumar, Raju, Arumugam, Natarajan, Basiri, Alireza, Kia, Yalda, Ashraf Ali, Mohamed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325472/ https://www.ncbi.nlm.nih.gov/pubmed/25710037 http://dx.doi.org/10.1155/2015/965987

Ejemplares similares

A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
por: Almansour, Abdulrahman I., et al.
Publicado: (2015)

An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction
por: Arumugam, Natarajan, et al.
Publicado: (2015)

Cholinesterase inhibitory activity of highly functionalized fluorinated spiropyrrolidine heterocyclic hybrids
por: Kumar, Raju Suresh, et al.
Publicado: (2021)

Design, Synthesis and In Vitro Mechanistic Investigation of Novel Hexacyclic Cage-Like Hybrid Heterocycles
por: Kumar, Raju Suresh, et al.
Publicado: (2019)

2-Hydroxy-5-[(E)-2-methylbenzylidene]-8-(2-methylphenyl)-9-phenyl-3,10-diazahexacyclo[10.7.1.1(3,7).0(2,11).0(7,11).0(16,20)]henicosa-1(20),12,14,16,18-pentaen-6-one
por: Almansour, Abdulrahman I., et al.
Publicado: (2012)

Environmentally friendly domino multicomponent strategy for the synthesis of pyrroloquinolinone hybrid heterocycles
por: Mani, Suresh, et al.
Publicado: (2022)

5-Chlorospiro[indoline-3,7′-6H,7H,8H-pyrano[3,2-c:5,6-c′]di[1]benzopyran]-2,6′,8′-trione
por: Almansour, Abdulrahman I., et al.
Publicado: (2012)

A One-Pot Three-Component Synthesis and Investigation of the In Vitro Mechanistic Anticancer Activity of Highly Functionalized Spirooxindole-Pyrrolidine Heterocyclic Hybrids
por: Kumar, Raju Suresh, et al.
Publicado: (2020)

5-Methylspiro[indoline-3,7′-[6H,7H,8H]pyrano[3,2-c:5,6-c′]di[1]benzopyran]-2,6′,8′-trione chloroform hemisolvate
por: Almansour, Abdulrahman I., et al.
Publicado: (2012)

(3E,5E)-1-Allyl-3,5-bis(4-methoxybenzylidene)piperidin-4-one
por: Almansour, Abdulrahman I., et al.
Publicado: (2013)

9-(2-Chlorobenzylidene)anthracen-10(9H)-one
por: Almansour, Abdulrahman I., et al.
Publicado: (2013)

A Sustainable Approach to the Stereoselective Synthesis of Diazaheptacyclic Cage Systems Based on a Multicomponent Strategy in an Ionic Liquid
por: Suresh Kumar, Raju, et al.
Publicado: (2016)

An Expedient Total Synthesis of Triciribine
por: Hu, Chen, et al.
Publicado: (2017)

Synthesis, Spectroscopic, X-ray Diffraction and DFT Studies of Novel Benzimidazole Fused-1,4-Oxazepines
por: Almansour, Abdulrahman I., et al.
Publicado: (2016)

In vitro Mechanistic Exploration of Novel Spiropyrrolidine Heterocyclic Hybrids as Anticancer Agents
por: Kumar, Raju Suresh, et al.
Publicado: (2020)

A Novel One-Pot Green Synthesis of Dispirooxindolo-pyrrolidines via1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides
por: Almansour, Abdulrahman I., et al.
Publicado: (2015)

5-Fluoro-6′H,7′H,8′H-spiro[indoline-3,7′-pyrano[3,2-c:5,6-c′]di-1-benzopyran]-2,6′,8′-trione
por: Almansour, Abdulrahman I., et al.
Publicado: (2012)

Discovery of diazahexa/hepta cyclic cage-like compounds with broad-spectrum antifungal activity against Candida and Cryptococcus species
por: Weinstock, Anthony, et al.
Publicado: (2019)

Expediency
Publicado: (1896)

1,6-Naphthyridin-2(1H)-ones: Synthesis and Biomedical Applications
por: Oliveras, Juan Marcos, et al.
Publicado: (2021)

Caspase dependent apoptotic activity of polycyclic cage-like heterocyclic hybrids
por: Kumar, Raju Suresh, et al.
Publicado: (2020)

D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity
por: Almansour, Abdulrahman I., et al.
Publicado: (2019)

[Bmim]Br Accelerated One-Pot Three-Component Cascade Protocol for the Construction of Spirooxindole–Pyrrolidine Heterocyclic Hybrids
por: Kumar, Raju Suresh, et al.
Publicado: (2020)

Highly functionalized pyrrolidine analogues: stereoselective synthesis and caspase-dependent apoptotic activity
por: Kumar, Raju Suresh, et al.
Publicado: (2018)

Unexpected Behavior of Enaminones: Interesting New Routes to 1,6-Naphthyridines, 2-Oxopyrrolidines and Pyrano[4,3,2-de][1,6]naphthyridines
por: Moustafa, Moustafa Sherief, et al.
Publicado: (2012)

(2RS,3SR,10SR,11RS)-3,10-Diphenoxy-18,21-dioxa-5,8-diazapentacyclo[20.4.0.0(2,5).0(8,11).0(12,17)]hexacosa-1(26),12,14,16,22,24-hexaene-4,9-dione ethyl acetate hemisolvate
por: Suresh, J., et al.
Publicado: (2011)

Expedient synthesis of 1,6-anhydro-α-D-galactofuranose, a useful intermediate for glycobiological tools
por: Baldoni, Luciana, et al.
Publicado: (2014)

Expedient synthesis of conjugated triynes via alkyne metathesis
por: Curbet, Idriss, et al.
Publicado: (2020)

Embryotomy—Novel Expedient
Publicado: (1874)

Expedient in Difficult Labor
Publicado: (1875)

Principle vs. Expediency
Publicado: (1892)

Surgical Expedients in Emergencies
Publicado: (1883)

A Novel Expedient
Publicado: (1885)

Expediency vs. Principle
Publicado: (1896)

Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors
por: Kulikova, Larisa N., et al.
Publicado: (2023)

Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase
por: Zhou, Xiang, et al.
Publicado: (2010)

1′′-Allyl-5′′-(4-methoxybenzylidene)-7′-(4-methoxyphenyl)-1′,3′,5′,6′,7′,7a′-hexahydrodispiro[acenaphthylene-1,5′-pyrrolo[1,2-c][1,3]thiazole-6′,3′′-piperidine]-2,4′′(1H)-dione
por: Almansour, Abulrahman I., et al.
Publicado: (2013)

Investigation of the one-step electrochemical deposition of graphene oxide-doped poly(3,4-ethylenedioxythiophene)–polyphenol oxidase as a dopamine sensor
por: Ramu, P., et al.
Publicado: (2022)

Domino Multicomponent Approach for the Synthesis of Functionalized Spiro-Indeno[1,2-b]quinoxaline Heterocyclic Hybrids and Their Antimicrobial Activity, Synergistic Effect and Molecular Docking Simulation
por: Almansour, Abdulrahman I., et al.
Publicado: (2019)

Regio- and diastereoselective synthesis of spiropyrroloquinoxaline grafted indole heterocyclic hybrids and evaluation of their anti-Mycobacterium tuberculosis activity
por: Arumugam, Natarajan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0c8smkk59cjb2hvdujlmi70ccc