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Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects
A conventional Mendelian randomization analysis assesses the causal effect of a risk factor on an outcome by using genetic variants that are solely associated with the risk factor of interest as instrumental variables. However, in some cases, such as the case of triglyceride level as a risk factor f...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325677/ https://www.ncbi.nlm.nih.gov/pubmed/25632051 http://dx.doi.org/10.1093/aje/kwu283 |