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Ex Vivo Lung Perfusion – State of the Art in Lung Donor Pool Expansion
Lung transplantation remains the gold standard for patients with end-stage lung disease. Nevertheless, the number of suitable donor lungs for the increasing number of patients on the waiting list necessitates alternative tools to expand the lung donor pool. Modern preservation and lung assessment te...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325829/ https://www.ncbi.nlm.nih.gov/pubmed/25644463 http://dx.doi.org/10.12659/MSMBR.893674 |
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author | Popov, Aron-Frederik Sabashnikov, Anton Patil, Nikhil P. Zeriouh, Mohamed Mohite, Prashant N. Zych, Bartlomiej Saez, Diana Garcia Schmack, Bastian Ruhparwar, Arjang Dohmen, Pascal M. Karck, Matthias Simon, Andre R. Weymann, Alexander |
author_facet | Popov, Aron-Frederik Sabashnikov, Anton Patil, Nikhil P. Zeriouh, Mohamed Mohite, Prashant N. Zych, Bartlomiej Saez, Diana Garcia Schmack, Bastian Ruhparwar, Arjang Dohmen, Pascal M. Karck, Matthias Simon, Andre R. Weymann, Alexander |
author_sort | Popov, Aron-Frederik |
collection | PubMed |
description | Lung transplantation remains the gold standard for patients with end-stage lung disease. Nevertheless, the number of suitable donor lungs for the increasing number of patients on the waiting list necessitates alternative tools to expand the lung donor pool. Modern preservation and lung assessment techniques could contribute to improved function in previously rejected lungs. Ex vivo lung perfusion (EVLP) already demonstrated its value in identification of transplantable grafts from the higher risk donor pool. Moreover, lungs from EVLP did not show significantly different postoperative results compared to standard criteria lungs. This could be explained by the reduction of the ischemia-reperfusion injury through EVLP application. The aim of this article is to review technical characteristics and the growing clinical EVLP experience with special attention to EVLP application for donation after cardiac death (DCD) lungs. |
format | Online Article Text |
id | pubmed-4325829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43258292015-02-17 Ex Vivo Lung Perfusion – State of the Art in Lung Donor Pool Expansion Popov, Aron-Frederik Sabashnikov, Anton Patil, Nikhil P. Zeriouh, Mohamed Mohite, Prashant N. Zych, Bartlomiej Saez, Diana Garcia Schmack, Bastian Ruhparwar, Arjang Dohmen, Pascal M. Karck, Matthias Simon, Andre R. Weymann, Alexander Med Sci Monit Basic Res Review Articles Lung transplantation remains the gold standard for patients with end-stage lung disease. Nevertheless, the number of suitable donor lungs for the increasing number of patients on the waiting list necessitates alternative tools to expand the lung donor pool. Modern preservation and lung assessment techniques could contribute to improved function in previously rejected lungs. Ex vivo lung perfusion (EVLP) already demonstrated its value in identification of transplantable grafts from the higher risk donor pool. Moreover, lungs from EVLP did not show significantly different postoperative results compared to standard criteria lungs. This could be explained by the reduction of the ischemia-reperfusion injury through EVLP application. The aim of this article is to review technical characteristics and the growing clinical EVLP experience with special attention to EVLP application for donation after cardiac death (DCD) lungs. International Scientific Literature, Inc. 2015-02-03 /pmc/articles/PMC4325829/ /pubmed/25644463 http://dx.doi.org/10.12659/MSMBR.893674 Text en © Med Sci Monit, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Review Articles Popov, Aron-Frederik Sabashnikov, Anton Patil, Nikhil P. Zeriouh, Mohamed Mohite, Prashant N. Zych, Bartlomiej Saez, Diana Garcia Schmack, Bastian Ruhparwar, Arjang Dohmen, Pascal M. Karck, Matthias Simon, Andre R. Weymann, Alexander Ex Vivo Lung Perfusion – State of the Art in Lung Donor Pool Expansion |
title | Ex Vivo Lung Perfusion – State of the Art in Lung Donor Pool Expansion |
title_full | Ex Vivo Lung Perfusion – State of the Art in Lung Donor Pool Expansion |
title_fullStr | Ex Vivo Lung Perfusion – State of the Art in Lung Donor Pool Expansion |
title_full_unstemmed | Ex Vivo Lung Perfusion – State of the Art in Lung Donor Pool Expansion |
title_short | Ex Vivo Lung Perfusion – State of the Art in Lung Donor Pool Expansion |
title_sort | ex vivo lung perfusion – state of the art in lung donor pool expansion |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325829/ https://www.ncbi.nlm.nih.gov/pubmed/25644463 http://dx.doi.org/10.12659/MSMBR.893674 |
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