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ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1)

Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that binds and transmits signals from various collagens in epithelial cells. However, how DDR1–dependent signaling is regulated has not been understood. Here we report that collagen binding induces ADAM10-dependent ectodomain shedding...

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Detalles Bibliográficos
Autores principales:	Shitomi, Yasuyuki, Thøgersen, Ida B., Ito, Noriko, Leitinger, Birgit, Enghild, Jan J., Itoh, Yoshifumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325837/ https://www.ncbi.nlm.nih.gov/pubmed/25540428 http://dx.doi.org/10.1091/mbc.E14-10-1463

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