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Genetic mosaic analysis of a deleterious mitochondrial DNA mutation in Drosophila reveals novel aspects of mitochondrial regulation and function

Various human diseases are associated with mitochondrial DNA (mtDNA) mutations, but heteroplasmy—the coexistence of mutant and wild-type mtDNA—complicates their study. We previously isolated a temperature-lethal mtDNA mutation in Drosophila, mt:CoI(T300I), which affects the cytochrome c oxidase subu...

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Detalles Bibliográficos
Autores principales:	Chen, Zhe, Qi, Yun, French, Stephanie, Zhang, Guofeng, Garcia, Raúl Covian, Balaban, Robert, Xu, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325838/ https://www.ncbi.nlm.nih.gov/pubmed/25501370 http://dx.doi.org/10.1091/mbc.E14-11-1513

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