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Fatigue in Multiple Sclerosis: A Look at the Role of Poor Sleep
Fatigue is a frequent and debilitating symptom of multiple sclerosis (MS) with rates ranging anywhere from 53 to 90%. Despite its high prevalence and grave impact on overall functioning and quality of life, the accurate definition, quantification, and etiology of fatigue have plagued the MS literatu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325921/ https://www.ncbi.nlm.nih.gov/pubmed/25729378 http://dx.doi.org/10.3389/fneur.2015.00021 |
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author | Strober, Lauren B. |
author_facet | Strober, Lauren B. |
author_sort | Strober, Lauren B. |
collection | PubMed |
description | Fatigue is a frequent and debilitating symptom of multiple sclerosis (MS) with rates ranging anywhere from 53 to 90%. Despite its high prevalence and grave impact on overall functioning and quality of life, the accurate definition, quantification, and etiology of fatigue have plagued the MS literature and clinical care for decades. With regard to its etiology, MS-related fatigue has been construed as being either primary or secondary. Primary fatigue is purported to be related to centrally mediated processes of the disease whereas secondary fatigue is thought to be a result of the host of factors that may accompany MS (e.g., depression, sleep disturbance). The present paper focuses on secondary fatigue and the role of sleep disturbance, in particular. Despite the intuitive assumption that sleep problems could contribute to fatigue, sleep problems in MS have gone fairly unrecognized until recently. The present paper provides a brief review of the literature pertaining to the prevalence and nature of sleep problems in MS as well as their association with fatigue. A replication of this author’s and others work is presented further demonstrating that sleep disturbance is a significant contributor to fatigue in MS when taking into account disease variables, depression, and sleep disturbance. |
format | Online Article Text |
id | pubmed-4325921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43259212015-02-27 Fatigue in Multiple Sclerosis: A Look at the Role of Poor Sleep Strober, Lauren B. Front Neurol Neuroscience Fatigue is a frequent and debilitating symptom of multiple sclerosis (MS) with rates ranging anywhere from 53 to 90%. Despite its high prevalence and grave impact on overall functioning and quality of life, the accurate definition, quantification, and etiology of fatigue have plagued the MS literature and clinical care for decades. With regard to its etiology, MS-related fatigue has been construed as being either primary or secondary. Primary fatigue is purported to be related to centrally mediated processes of the disease whereas secondary fatigue is thought to be a result of the host of factors that may accompany MS (e.g., depression, sleep disturbance). The present paper focuses on secondary fatigue and the role of sleep disturbance, in particular. Despite the intuitive assumption that sleep problems could contribute to fatigue, sleep problems in MS have gone fairly unrecognized until recently. The present paper provides a brief review of the literature pertaining to the prevalence and nature of sleep problems in MS as well as their association with fatigue. A replication of this author’s and others work is presented further demonstrating that sleep disturbance is a significant contributor to fatigue in MS when taking into account disease variables, depression, and sleep disturbance. Frontiers Media S.A. 2015-02-12 /pmc/articles/PMC4325921/ /pubmed/25729378 http://dx.doi.org/10.3389/fneur.2015.00021 Text en Copyright © 2015 Strober. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Strober, Lauren B. Fatigue in Multiple Sclerosis: A Look at the Role of Poor Sleep |
title | Fatigue in Multiple Sclerosis: A Look at the Role of Poor Sleep |
title_full | Fatigue in Multiple Sclerosis: A Look at the Role of Poor Sleep |
title_fullStr | Fatigue in Multiple Sclerosis: A Look at the Role of Poor Sleep |
title_full_unstemmed | Fatigue in Multiple Sclerosis: A Look at the Role of Poor Sleep |
title_short | Fatigue in Multiple Sclerosis: A Look at the Role of Poor Sleep |
title_sort | fatigue in multiple sclerosis: a look at the role of poor sleep |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325921/ https://www.ncbi.nlm.nih.gov/pubmed/25729378 http://dx.doi.org/10.3389/fneur.2015.00021 |
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