Abacavir-Reactive Memory T Cells Are Present in Drug Naïve Individuals

BACKGROUND: Fifty-five percent of individuals with HLA-B*57:01 exposed to the antiretroviral drug abacavir develop a hypersensitivity reaction (HSR) that has been attributed to naïve T-cell responses to neo-antigen generated by the drug. Immunologically confirmed abacavir HSR can manifest clinically...

Descripción completa

Detalles Bibliográficos
Autores principales: Lucas, Andrew, Lucas, Michaela, Strhyn, Anette, Keane, Niamh M., McKinnon, Elizabeth, Pavlos, Rebecca, Moran, Ellen M., Meyer-Pannwitt, Viola, Gaudieri, Silvana, D’Orsogna, Lloyd, Kalams, Spyros, Ostrov, David A., Buus, Søren, Peters, Bjoern, Mallal, Simon, Phillips, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326126/
https://www.ncbi.nlm.nih.gov/pubmed/25674793
http://dx.doi.org/10.1371/journal.pone.0117160

Ejemplares similares

Ejemplares similares