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Comprehensive Profiling of Plasma Fatty Acid Concentrations in Young Healthy Canadian Adults

Circulating fatty acids (FA) are associated with a multitude of chronic diseases. However, a major gap in establishing such relationships is the lack of accepted fatty acid reference ranges representing healthy individuals. Data on validated FA reference ranges would provide a better understanding o...

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Autores principales: Abdelmagid, Salma A., Clarke, Shannon E., Nielsen, Daiva E., Badawi, Alaa, El-Sohemy, Ahmed, Mutch, David M., Ma, David W. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326172/
https://www.ncbi.nlm.nih.gov/pubmed/25675440
http://dx.doi.org/10.1371/journal.pone.0116195
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author Abdelmagid, Salma A.
Clarke, Shannon E.
Nielsen, Daiva E.
Badawi, Alaa
El-Sohemy, Ahmed
Mutch, David M.
Ma, David W. L.
author_facet Abdelmagid, Salma A.
Clarke, Shannon E.
Nielsen, Daiva E.
Badawi, Alaa
El-Sohemy, Ahmed
Mutch, David M.
Ma, David W. L.
author_sort Abdelmagid, Salma A.
collection PubMed
description Circulating fatty acids (FA) are associated with a multitude of chronic diseases. However, a major gap in establishing such relationships is the lack of accepted fatty acid reference ranges representing healthy individuals. Data on validated FA reference ranges would provide a better understanding of study baseline measures and aid in the evaluation and interpretation of pharmaceutical or dietary interventions. Reference ranges for plasma FA levels have been reported in a few small studies and on a limited number of FA. Therefore, we determined the average and percentiles of a broad set of 61 FA (C14 - C24:1) from plasma total lipids from an ethnically diverse population of healthy young Canadian males and females (Total n = 826). Plasma concentrations of some of the major FA ranged from 0.3 to 4.1 mmol/L for palmitic acid, 0.1 to 1.0 mmol/L for stearic acid, 0.03 to 3.2 mmol/L for oleic acid, 0.2 to 5.0 mmol/L for linoleic acid (LA), 12.0 to 186.9 μmol/L for α-linolenic acid, and 7.2 to 237.5 μmol/L for docosahexaenoic acid (DHA). Males had significantly higher plasma concentrations of γ-linolenic acid (GLA) and n-3 docosapentaenoic acid and lower concentrations of palmitoleic acid, LA and DHA than females. Comparison of FA concentrations between Caucasians, East Asians and South Asians revealed that South Asians had significantly lower levels of palmitoleic acid (p < 0.01) and oleic acid (p = 0.01) while East Asians had lower levels of GLA (p = 0.02) and dihomo-γ-linolenic acid (p = 0.03). Overall, these data provide a comprehensive set of quantitative values that profiles a small cohort of Canadians which highlights the utility of establishing validated FA reference ranges that may be used to understand how deficient, suboptimal, or excess amounts of a given FA may be associated with chronic disease.
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spelling pubmed-43261722015-02-24 Comprehensive Profiling of Plasma Fatty Acid Concentrations in Young Healthy Canadian Adults Abdelmagid, Salma A. Clarke, Shannon E. Nielsen, Daiva E. Badawi, Alaa El-Sohemy, Ahmed Mutch, David M. Ma, David W. L. PLoS One Research Article Circulating fatty acids (FA) are associated with a multitude of chronic diseases. However, a major gap in establishing such relationships is the lack of accepted fatty acid reference ranges representing healthy individuals. Data on validated FA reference ranges would provide a better understanding of study baseline measures and aid in the evaluation and interpretation of pharmaceutical or dietary interventions. Reference ranges for plasma FA levels have been reported in a few small studies and on a limited number of FA. Therefore, we determined the average and percentiles of a broad set of 61 FA (C14 - C24:1) from plasma total lipids from an ethnically diverse population of healthy young Canadian males and females (Total n = 826). Plasma concentrations of some of the major FA ranged from 0.3 to 4.1 mmol/L for palmitic acid, 0.1 to 1.0 mmol/L for stearic acid, 0.03 to 3.2 mmol/L for oleic acid, 0.2 to 5.0 mmol/L for linoleic acid (LA), 12.0 to 186.9 μmol/L for α-linolenic acid, and 7.2 to 237.5 μmol/L for docosahexaenoic acid (DHA). Males had significantly higher plasma concentrations of γ-linolenic acid (GLA) and n-3 docosapentaenoic acid and lower concentrations of palmitoleic acid, LA and DHA than females. Comparison of FA concentrations between Caucasians, East Asians and South Asians revealed that South Asians had significantly lower levels of palmitoleic acid (p < 0.01) and oleic acid (p = 0.01) while East Asians had lower levels of GLA (p = 0.02) and dihomo-γ-linolenic acid (p = 0.03). Overall, these data provide a comprehensive set of quantitative values that profiles a small cohort of Canadians which highlights the utility of establishing validated FA reference ranges that may be used to understand how deficient, suboptimal, or excess amounts of a given FA may be associated with chronic disease. Public Library of Science 2015-02-12 /pmc/articles/PMC4326172/ /pubmed/25675440 http://dx.doi.org/10.1371/journal.pone.0116195 Text en © 2015 Abdelmagid et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Abdelmagid, Salma A.
Clarke, Shannon E.
Nielsen, Daiva E.
Badawi, Alaa
El-Sohemy, Ahmed
Mutch, David M.
Ma, David W. L.
Comprehensive Profiling of Plasma Fatty Acid Concentrations in Young Healthy Canadian Adults
title Comprehensive Profiling of Plasma Fatty Acid Concentrations in Young Healthy Canadian Adults
title_full Comprehensive Profiling of Plasma Fatty Acid Concentrations in Young Healthy Canadian Adults
title_fullStr Comprehensive Profiling of Plasma Fatty Acid Concentrations in Young Healthy Canadian Adults
title_full_unstemmed Comprehensive Profiling of Plasma Fatty Acid Concentrations in Young Healthy Canadian Adults
title_short Comprehensive Profiling of Plasma Fatty Acid Concentrations in Young Healthy Canadian Adults
title_sort comprehensive profiling of plasma fatty acid concentrations in young healthy canadian adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326172/
https://www.ncbi.nlm.nih.gov/pubmed/25675440
http://dx.doi.org/10.1371/journal.pone.0116195
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