Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation

Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenge after allogeneic hematopoietic progenitor cell transplantation, considering the diagnostic uncertainties and lack of established treatment. We report a 43-year-old male patient who was diagnosed as TA-TMA after allogeneic...

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Autores principales: Sevindik, Ömür Gökmen, Alacacıoğlu, İnci, Katgı, Abdullah, Solmaz, Şerife Medeni, Acar, Celal, Pişkin, Özden, Özcan, Mehmet Ali, Demirkan, Fatih, Ündar, Bülent, Özsan, Güner Hayri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326272/
https://www.ncbi.nlm.nih.gov/pubmed/25705530
http://dx.doi.org/10.1155/2015/425410
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author Sevindik, Ömür Gökmen
Alacacıoğlu, İnci
Katgı, Abdullah
Solmaz, Şerife Medeni
Acar, Celal
Pişkin, Özden
Özcan, Mehmet Ali
Demirkan, Fatih
Ündar, Bülent
Özsan, Güner Hayri
author_facet Sevindik, Ömür Gökmen
Alacacıoğlu, İnci
Katgı, Abdullah
Solmaz, Şerife Medeni
Acar, Celal
Pişkin, Özden
Özcan, Mehmet Ali
Demirkan, Fatih
Ündar, Bülent
Özsan, Güner Hayri
author_sort Sevindik, Ömür Gökmen
collection PubMed
description Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenge after allogeneic hematopoietic progenitor cell transplantation, considering the diagnostic uncertainties and lack of established treatment. We report a 43-year-old male patient who was diagnosed as TA-TMA after allogeneic progenitor cell transplantation for a progressive ALK negative anaplastic large cell lymphoma and responded to eculizumab with dramatically improving neurological status and renal function. Rapid neurological and renal recovery achieved after eculizumab could support a possible relationship between complement activation and TA-TMA. Eculizumab should be a reasonable treatment approach in patients with TA-TMA after allogeneic hematopoietic progenitor cell transplantation.
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spelling pubmed-43262722015-02-22 Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation Sevindik, Ömür Gökmen Alacacıoğlu, İnci Katgı, Abdullah Solmaz, Şerife Medeni Acar, Celal Pişkin, Özden Özcan, Mehmet Ali Demirkan, Fatih Ündar, Bülent Özsan, Güner Hayri Case Rep Hematol Case Report Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenge after allogeneic hematopoietic progenitor cell transplantation, considering the diagnostic uncertainties and lack of established treatment. We report a 43-year-old male patient who was diagnosed as TA-TMA after allogeneic progenitor cell transplantation for a progressive ALK negative anaplastic large cell lymphoma and responded to eculizumab with dramatically improving neurological status and renal function. Rapid neurological and renal recovery achieved after eculizumab could support a possible relationship between complement activation and TA-TMA. Eculizumab should be a reasonable treatment approach in patients with TA-TMA after allogeneic hematopoietic progenitor cell transplantation. Hindawi Publishing Corporation 2015 2015-01-29 /pmc/articles/PMC4326272/ /pubmed/25705530 http://dx.doi.org/10.1155/2015/425410 Text en Copyright © 2015 Ömür Gökmen Sevindik et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sevindik, Ömür Gökmen
Alacacıoğlu, İnci
Katgı, Abdullah
Solmaz, Şerife Medeni
Acar, Celal
Pişkin, Özden
Özcan, Mehmet Ali
Demirkan, Fatih
Ündar, Bülent
Özsan, Güner Hayri
Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation
title Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation
title_full Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation
title_fullStr Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation
title_full_unstemmed Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation
title_short Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation
title_sort renal and neurological response with eculizumab in a patient with transplant associated thrombotic microangiopathy after allogeneic hematopoietic progenitor cell transplantation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326272/
https://www.ncbi.nlm.nih.gov/pubmed/25705530
http://dx.doi.org/10.1155/2015/425410
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