Cargando…

RAD18 Activates the G2/M Checkpoint through DNA Damage Signaling to Maintain Genome Integrity after Ionizing Radiation Exposure

The ubiquitin ligase RAD18 is involved in post replication repair pathways via its recruitment to stalled replication forks, and its role in the ubiquitylation of proliferating cell nuclear antigen (PCNA). Recently, it has been reported that RAD18 is also recruited to DNA double strand break (DSB) s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sasatani, Megumi, Xu, Yanbin, Kawai, Hidehiko, Cao, Lili, Tateishi, Satoshi, Shimura, Tsutomu, Li, Jianxiang, Iizuka, Daisuke, Noda, Asao, Hamasaki, Kanya, Kusunoki, Yoichiro, Kamiya, Kenji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326275/ https://www.ncbi.nlm.nih.gov/pubmed/25675240 http://dx.doi.org/10.1371/journal.pone.0117845

Ejemplares similares

Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level
por: Sasatani, Megumi, et al.
Publicado: (2017)

Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in lowdose irradiated human fibroblasts
por: Shimura, Tsutomu, et al.
Publicado: (2015)

Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in Apc(Min/+) mice: possible mechanisms of radiation tumorigenesis
por: Sasatani, Megumi, et al.
Publicado: (2022)

A Novel ATM/TP53/p21-Mediated Checkpoint Only Activated by Chronic γ-Irradiation
por: Cao, Lili, et al.
Publicado: (2014)

Melatonin and MitoEbselen-2 Are Radioprotective Agents to Mitochondria
por: Shimura, Tsutomu, et al.
Publicado: (2022)

Spectra and characteristics of somatic mutations induced by ionizing radiation in hematopoietic stem cells
por: Matsuda, Yukiko, et al.
Publicado: (2023)

Radiation affects glutathione redox reaction by reduced glutathione peroxidase activity in human fibroblasts
por: Shimura, Tsutomu, et al.
Publicado: (2021)

Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A–RAD18 ternary complex
por: Masuda, Yuji, et al.
Publicado: (2012)

Progerin, the protein responsible for the Hutchinson-Gilford progeria syndrome, increases the unrepaired DNA damages following exposure to ionizing radiation
por: Noda, Asao, et al.
Publicado: (2015)

Newly discovered genomic mutation patterns in radiation-induced small intestinal tumors of Apc(Min/+) mice
por: Iizuka, Daisuke, et al.
Publicado: (2023)

Translocations are induced in hematopoietic stem cells after irradiation of fetal mice
por: Hamasaki, Kanya, et al.
Publicado: (2022)

The in vivo role of Rev1 in mutagenesis and carcinogenesis
por: Sasatani, Megumi, et al.
Publicado: (2020)

Creation of Mice Bearing a Partial Duplication of HPRT Gene Marked with a GFP Gene and Detection of Revertant Cells In Situ as GFP-Positive Somatic Cells
por: Noda, Asao, et al.
Publicado: (2015)

Metabolomic screening using ESI-FT MS identifies potential radiation-responsive molecules in mouse urine
por: Iizuka, Daisuke, et al.
Publicado: (2017)

Massive expansion of multiple clones in the mouse hematopoietic system long after whole-body X-irradiation
por: Yoshida, Kengo, et al.
Publicado: (2022)

CDC5 Inhibits the Hyperphosphorylation of the Checkpoint Kinase Rad53, Leading to Checkpoint Adaptation
por: Vidanes, Genevieve M., et al.
Publicado: (2010)

The human checkpoint sensor Rad9–Rad1–Hus1 interacts with and stimulates NEIL1 glycosylase
por: Guan, Xin, et al.
Publicado: (2007)

Modulation of fatty acid synthase by ATR checkpoint kinase Rad3
por: Qiu, Shuwan, et al.
Publicado: (2019)

Hepcidin-2 in mouse urine as a candidate radiation-responsive molecule
por: Iizuka, Daisuke, et al.
Publicado: (2016)

Impact of GigaRad Ionizing Dose on 28 nm bulk MOSFETs for future HL-LHC
por: Pezzotta, A, et al.
Publicado: (2016)

Characterization of GigaRad Total Ionizing Dose and Annealing Effects on 28-nm Bulk MOSFETs
por: Zhang, Chun-Min, et al.
Publicado: (2017)

GigaRad total ionizing dose and post-irradiation effects on 28 nm bulk MOSFETs
por: Zhang, C M, et al.
Publicado: (2017)

The human checkpoint sensor Rad9–Rad1–Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase
por: Guan, Xin, et al.
Publicado: (2007)

Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation
por: Meng, Qingmei, et al.
Publicado: (2021)

RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation
por: Badie, Sophie, et al.
Publicado: (2009)

DNA Repair Scaffolds Dampen Checkpoint Signaling by Counteracting the Rad9 Adaptor
por: Ohouo, Patrice Y., et al.
Publicado: (2012)

Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition
por: Shen, John Paul, et al.
Publicado: (2015)

Dynamics of Above-Threshold Ionization and Laser-Assisted Electron Scattering inside Helium Nanodroplets
por: Treiber, Leonhard, et al.
Publicado: (2022)

The Onset of Dental Erosion Caused by Food and Drinks and the Preventive Effect of Alkaline Ionized Water
por: Sato, Tsutomu, et al.
Publicado: (2021)

TAZ maintains telomere length in TNBC cells by mediating Rad51C expression
por: Yang, Lu, et al.
Publicado: (2021)

Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast
por: Fersht, Naomi, et al.
Publicado: (2007)

Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function
por: Murfuni, Ivana, et al.
Publicado: (2013)

The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1
por: Lao, Jessica P., et al.
Publicado: (2018)

Yeast Stn1 promotes MCM to circumvent Rad53 control of the S phase checkpoint
por: Gasparayan, Hovik, et al.
Publicado: (2022)

Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters
por: Sheu, Yi-Jun, et al.
Publicado: (2022)

Radiation-induced unrepairable DSBs: their role in the late effects of radiation and possible applications to biodosimetry
por: Noda, Asao
Publicado: (2018)

SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9–Rad1–Hus1 checkpoint clamp
por: Hwang, Bor-Jang, et al.
Publicado: (2015)

An ordered assembly of MYH glycosylase, SIRT6 protein deacetylase, and Rad9-Rad1-Hus1 checkpoint clamp at oxidatively damaged telomeres
por: Tan, Jun, et al.
Publicado: (2020)

Mutation and apoptosis are well-coordinated for protecting against DNA damage-inducing toxicity in Drosophila
por: Toyoshima-Sasatani, Megumi, et al.
Publicado: (2023)

Breast imaging reports for malignant lesions: are we maintaining recommended BI-RADS(®) lexicon standards?
por: Masroor, Imrana, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_pfhrp81rqem8h9jo7l7rj7fld6