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Are special read alignment strategies necessary and cost-effective when handling sequencing reads from patient-derived tumor xenografts?

BACKGROUND: Patient-derived tumor xenografts in mice are widely used in cancer research and have become important in developing personalized therapies. When these xenografts are subject to DNA sequencing, the samples could contain various amounts of mouse DNA. It has been unclear how the mouse reads...

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Detalles Bibliográficos
Autores principales:	Tso, Kai-Yuen, Lee, Sau Dan, Lo, Kwok-Wai, Yip, Kevin Y
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326289/ https://www.ncbi.nlm.nih.gov/pubmed/25539684 http://dx.doi.org/10.1186/1471-2164-15-1172

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