Cargando…

Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma

BACKGROUND: ADAR enzymes convert adenosines to inosines within double-stranded RNAs, including microRNA (miRNA) precursors, with important consequences on miRNA retargeting and expression. ADAR2 activity is impaired in glioblastoma and its rescue has anti-tumoral effects. However, how ADAR2 activity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tomaselli, Sara, Galeano, Federica, Alon, Shahar, Raho, Susanna, Galardi, Silvia, Polito, Vinicia Assunta, Presutti, Carlo, Vincenti, Sara, Eisenberg, Eli, Locatelli, Franco, Gallo, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326501/ https://www.ncbi.nlm.nih.gov/pubmed/25582055 http://dx.doi.org/10.1186/s13059-014-0575-z

Ejemplares similares

ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion
por: Cesarini, Valeriana, et al.
Publicado: (2018)

ADAR2 editing activity in newly diagnosed versus relapsed pediatric high-grade astrocytomas
por: Tomaselli, Sara, et al.
Publicado: (2013)

ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis
por: Galeano, F, et al.
Publicado: (2013)

Systematic identification of edited microRNAs in the human brain
por: Alon, Shahar, et al.
Publicado: (2012)

Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes
por: Keegan, Liam P, et al.
Publicado: (2004)

ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism
por: Tassinari, Valentina, et al.
Publicado: (2021)

ADAR Enzyme and miRNA Story: A Nucleotide that Can Make the Difference
por: Tomaselli, Sara, et al.
Publicado: (2013)

Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection
por: Doria, Margherita, et al.
Publicado: (2009)

Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2
por: Phelps, Kelly J., et al.
Publicado: (2015)

Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity
por: Katrekar, Dhruva, et al.
Publicado: (2022)

Examination of Factors Affecting Site-Directed RNA Editing by the MS2-ADAR1 Deaminase System
por: Azad, Md Thoufic Anam, et al.
Publicado: (2023)

The RNA editing enzyme ADAR2 restricts L1 mobility
por: Frassinelli, Loredana, et al.
Publicado: (2021)

Oligophrenin-1 (OPHN1), a Gene Involved in X-Linked Intellectual Disability, Undergoes RNA Editing and Alternative Splicing during Human Brain Development
por: Barresi, Sabina, et al.
Publicado: (2014)

Optimal guideRNAs for re-directing deaminase activity of hADAR1 and hADAR2 in trans
por: Schneider, Marius F., et al.
Publicado: (2014)

A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma
por: Chan, Tim Hon Man, et al.
Publicado: (2014)

A Novel Computational Strategy to Identify A-to-I RNA Editing Sites by RNA-Seq Data: De Novo Detection in Human Spinal Cord Tissue
por: Picardi, Ernesto, et al.
Publicado: (2012)

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms
por: Kleinova, Renata, et al.
Publicado: (2023)

Promoting RNA editing by ADAR attraction
por: Danan-Gotthold, Miri, et al.
Publicado: (2017)

ADAR RNA editing below the backbone
por: Keegan, Liam, et al.
Publicado: (2017)

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
por: Gannon, Hugh S., et al.
Publicado: (2018)

ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance
por: Jiang, Li, et al.
Publicado: (2022)

ADAR2 Protein Is Associated with Overall Survival in GBM Patients and Its Decrease Triggers the Anchorage-Independent Cell Growth Signature
por: Cesarini, Valeriana, et al.
Publicado: (2022)

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins
por: Mannion, Niamh, et al.
Publicado: (2015)

The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing
por: Alon, Shahar, et al.
Publicado: (2015)

Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses
por: Tang, Qiannan, et al.
Publicado: (2021)

Adenosine Deaminase Acting on RNA (ADAR) Enzymes: A Journey from Weird to Wondrous
por: Keegan, Liam P., et al.
Publicado: (2023)

ADAR1 Editing and its Role in Cancer
por: Xu, Li-Di, et al.
Publicado: (2018)

ADAR Editing in Viruses: An Evolutionary Force to Reckon with
por: Piontkivska, Helen, et al.
Publicado: (2021)

Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
por: Gannon, Hugh S., et al.
Publicado: (2022)

Predicting sites of ADAR editing in double-stranded RNA
por: Eggington, Julie M., et al.
Publicado: (2011)

The origin of the ADAR gene family and animal RNA editing
por: Grice, Laura F, et al.
Publicado: (2015)

RNA Editing, ADAR1, and the Innate Immune Response
por: Wang, Qingde, et al.
Publicado: (2017)

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
por: Walkley, Carl R., et al.
Publicado: (2017)

ADAR1 restricts LINE-1 retrotransposition
por: Orecchini, Elisa, et al.
Publicado: (2017)

A-to-I RNA Editing in the Earliest-Diverging Eumetazoan Phyla
por: Porath, Hagit T., et al.
Publicado: (2017)

Cleavage of dsRNAs hyper-edited by ADARs occurs at preferred editing sites
por: Scadden, A. D. J., et al.
Publicado: (2005)

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects
por: Keegan, Liam P., et al.
Publicado: (2011)

Squid express conserved ADAR orthologs that possess novel features
por: Vallecillo-Viejo, Isabel C., et al.
Publicado: (2023)

Modulation of ADAR1 editing activity by Z-RNA in vitro
por: Koeris, Michael, et al.
Publicado: (2005)

Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR
por: Marcucci, Roberto, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_569sd8fa11ulc2q1it4o9jgpeh