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Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage

BACKGROUND: In complex with its cofactor UAF1, the USP1 deubiquitinase plays an important role in cellular processes related to cancer, including the response to DNA damage. The USP1/UAF1 complex is emerging as a novel target in cancer therapy, but several aspects of its function and regulation rema...

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Detalles Bibliográficos
Autores principales:	Olazabal-Herrero, Anne, García-Santisteban, Iraia, Rodríguez, Jose Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326527/ https://www.ncbi.nlm.nih.gov/pubmed/25744535 http://dx.doi.org/10.1186/s12943-015-0311-7

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