Cargando…
Autosis and autophagic cell death: the dark side of autophagy
It is controversial whether cells truly die via autophagy or whether — in dying cells — autophagy is merely an innocent bystander or a well-intentioned ‘Good Samaritan' trying to prevent inevitable cellular demise. However, there is increasing evidence that the genetic machinery of autophagy ma...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326571/ https://www.ncbi.nlm.nih.gov/pubmed/25257169 http://dx.doi.org/10.1038/cdd.2014.143 |
_version_ | 1782356952698847232 |
---|---|
author | Liu, Y Levine, B |
author_facet | Liu, Y Levine, B |
author_sort | Liu, Y |
collection | PubMed |
description | It is controversial whether cells truly die via autophagy or whether — in dying cells — autophagy is merely an innocent bystander or a well-intentioned ‘Good Samaritan' trying to prevent inevitable cellular demise. However, there is increasing evidence that the genetic machinery of autophagy may be essential for cell death in certain settings. We recently identified a novel form of autophagy gene-dependent cell death, termed autosis, which is mediated by the Na(+),K(+)-ATPase pump and has unique morphological features. High levels of cellular autophagy, as occurs with treatment with autophagy-inducing peptides, starvation, or in vivo during certain types of ischemia, can trigger autosis. These findings provide insights into the mechanisms and strategies for prevention of cell death during extreme stress conditions. |
format | Online Article Text |
id | pubmed-4326571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-43265712015-03-01 Autosis and autophagic cell death: the dark side of autophagy Liu, Y Levine, B Cell Death Differ Review It is controversial whether cells truly die via autophagy or whether — in dying cells — autophagy is merely an innocent bystander or a well-intentioned ‘Good Samaritan' trying to prevent inevitable cellular demise. However, there is increasing evidence that the genetic machinery of autophagy may be essential for cell death in certain settings. We recently identified a novel form of autophagy gene-dependent cell death, termed autosis, which is mediated by the Na(+),K(+)-ATPase pump and has unique morphological features. High levels of cellular autophagy, as occurs with treatment with autophagy-inducing peptides, starvation, or in vivo during certain types of ischemia, can trigger autosis. These findings provide insights into the mechanisms and strategies for prevention of cell death during extreme stress conditions. Nature Publishing Group 2015-03 2014-09-26 /pmc/articles/PMC4326571/ /pubmed/25257169 http://dx.doi.org/10.1038/cdd.2014.143 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Review Liu, Y Levine, B Autosis and autophagic cell death: the dark side of autophagy |
title | Autosis and autophagic cell death: the dark side of autophagy |
title_full | Autosis and autophagic cell death: the dark side of autophagy |
title_fullStr | Autosis and autophagic cell death: the dark side of autophagy |
title_full_unstemmed | Autosis and autophagic cell death: the dark side of autophagy |
title_short | Autosis and autophagic cell death: the dark side of autophagy |
title_sort | autosis and autophagic cell death: the dark side of autophagy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326571/ https://www.ncbi.nlm.nih.gov/pubmed/25257169 http://dx.doi.org/10.1038/cdd.2014.143 |
work_keys_str_mv | AT liuy autosisandautophagiccelldeaththedarksideofautophagy AT levineb autosisandautophagiccelldeaththedarksideofautophagy |