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PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s
The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was initially identified through its role in the regulation of glucose and lipid metabolism and cell differentiation. It also infl...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326663/ https://www.ncbi.nlm.nih.gov/pubmed/25007880 http://dx.doi.org/10.1007/s11064-014-1377-0 |
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author | Corona, Juan Carlos Duchen, Michael R. |
author_facet | Corona, Juan Carlos Duchen, Michael R. |
author_sort | Corona, Juan Carlos |
collection | PubMed |
description | The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was initially identified through its role in the regulation of glucose and lipid metabolism and cell differentiation. It also influences the expression or activity of a number of genes in a variety of signalling networks. These include regulation of redox balance, fatty acid oxidation, immune responses and mitochondrial function. Recent studies suggest that the PPARγ agonists may serve as good candidates for the treatment of several neurodegenerative disorders including Parkinson’s disease (PD), Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis, even though multiple etiological factors contribute to the development of these disorders. Recent reports have also signposted a role for PPARγ coactivator-1α (PGC-1α) in several neurodegenerative disorders including PD. In this review, we explore the current knowledge of mechanisms underlying the beneficial effects of PPARγ agonists and PGC-1α in models of PD. |
format | Online Article Text |
id | pubmed-4326663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-43266632015-02-19 PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s Corona, Juan Carlos Duchen, Michael R. Neurochem Res Overview The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was initially identified through its role in the regulation of glucose and lipid metabolism and cell differentiation. It also influences the expression or activity of a number of genes in a variety of signalling networks. These include regulation of redox balance, fatty acid oxidation, immune responses and mitochondrial function. Recent studies suggest that the PPARγ agonists may serve as good candidates for the treatment of several neurodegenerative disorders including Parkinson’s disease (PD), Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis, even though multiple etiological factors contribute to the development of these disorders. Recent reports have also signposted a role for PPARγ coactivator-1α (PGC-1α) in several neurodegenerative disorders including PD. In this review, we explore the current knowledge of mechanisms underlying the beneficial effects of PPARγ agonists and PGC-1α in models of PD. Springer US 2014-07-10 2015 /pmc/articles/PMC4326663/ /pubmed/25007880 http://dx.doi.org/10.1007/s11064-014-1377-0 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Overview Corona, Juan Carlos Duchen, Michael R. PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s |
title | PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s |
title_full | PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s |
title_fullStr | PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s |
title_full_unstemmed | PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s |
title_short | PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s |
title_sort | pparγ and pgc-1α as therapeutic targets in parkinson’s |
topic | Overview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326663/ https://www.ncbi.nlm.nih.gov/pubmed/25007880 http://dx.doi.org/10.1007/s11064-014-1377-0 |
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