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Use of stereotypical mutational motifs to define resolution limits for the ultra-deep resequencing of mitochondrial DNA
Massively parallel resequencing of mitochondrial DNA (mtDNA) has led to significant advances in the study of heteroplasmic mtDNA variants in health and disease, but confident resolution of very low-level variants (<2% heteroplasmy) remains challenging due to the difficulty in distinguishing signa...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326723/ https://www.ncbi.nlm.nih.gov/pubmed/24896153 http://dx.doi.org/10.1038/ejhg.2014.96 |