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Single Molecule Analysis of Functionally Asymmetric G Protein-coupled Receptor (GPCR) Oligomers Reveals Diverse Spatial and Structural Assemblies

Formation of G protein-coupled receptors (GPCRs) into dimers and higher order oligomers represents a key mechanism in pleiotropic signaling, yet how individual protomers function within oligomers remains poorly understood. We present a super-resolution imaging approach, resolving single GPCR molecul...

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Detalles Bibliográficos
Autores principales:	Jonas, Kim C., Fanelli, Francesca, Huhtaniemi, Ilpo T., Hanyaloglu, Aylin C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326798/ https://www.ncbi.nlm.nih.gov/pubmed/25516594 http://dx.doi.org/10.1074/jbc.M114.622498

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