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Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer’s disease
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by pathological deposits of β-amyloid (Aβ) in senile plaques, intracellular neurofibrillary tangles (NFTs) comprising hyperphosphorylated aggregated tau, synaptic dysfunction and neuronal death. Substantial evidence indicates tha...
Autores principales: | Atherton, Joe, Kurbatskaya, Ksenia, Bondulich, Marie, Croft, Cara L, Garwood, Claire J, Chhabra, Resham, Wray, Selina, Jeromin, Andreas, Hanger, Diane P, Noble, Wendy |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326873/ https://www.ncbi.nlm.nih.gov/pubmed/23919677 http://dx.doi.org/10.1111/acel.12148 |
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