The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

To re-examine the correlation between mtDNA variability and longevity, we examined mtDNAs from samples obtained from over 2200 ultranonagenarians (and an equal number of controls) collected within the framework of the GEHA EU project. The samples were categorized by high-resolution classification, w...

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Detalles Bibliográficos
Autores principales: Raule, Nicola, Sevini, Federica, Li, Shengting, Barbieri, Annalaura, Tallaro, Federica, Lomartire, Laura, Vianello, Dario, Montesanto, Alberto, Moilanen, Jukka S, Bezrukov, Vladyslav, Blanché, Hélène, Hervonen, Antti, Christensen, Kaare, Deiana, Luca, Gonos, Efstathios S, Kirkwood, Tom B L, Kristensen, Peter, Leon, Alberta, Pelicci, Pier Giuseppe, Poulain, Michel, Rea, Irene M, Remacle, Josè, Robine, Jean Marie, Schreiber, Stefan, Sikora, Ewa, Eline Slagboom, Peternella, Spazzafumo, Liana, Antonietta Stazi, Maria, Toussaint, Olivier, Vaupel, James W, Rose, Giuseppina, Majamaa, Kari, Perola, Markus, Johnson, Thomas E, Bolund, Lars, Yang, Huanming, Passarino, Giuseppe, Franceschi, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326891/
https://www.ncbi.nlm.nih.gov/pubmed/24341918
http://dx.doi.org/10.1111/acel.12186

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