Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer’s disease

Several studies support the relation between leptin and Alzheimer’s disease (AD). We show that leptin levels in CSF are unchanged as subjects progress to AD. However, in AD hippocampus, leptin signalling was decreased and leptin localization was shifted, being more abundant in reactive astrocytes an...

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Detalles Bibliográficos
Autores principales: Maioli, Silvia, Lodeiro, Maria, Merino-Serrais, Paula, Falahati, Farshad, Khan, Wasim, Puerta, Elena, Codita, Alina, Rimondini, Roberto, Ramirez, Maria J, Simmons, Andrew, Gil-Bea, Francisco, Westman, Eric, Cedazo-Minguez, Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326905/
https://www.ncbi.nlm.nih.gov/pubmed/25453257
http://dx.doi.org/10.1111/acel.12281

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