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Age-associated reduction of cellular spreading/mechanical force up-regulates matrix metalloproteinase-1 expression and collagen fibril fragmentation via c-Jun/AP-1 in human dermal fibroblasts

The dermal compartment of human skin is largely composed of dense collagen-rich fibrils, which provide structural and mechanical support. Skin dermal fibroblasts, the major collagen-producing cells, are interact with collagen fibrils to maintain cell spreading and mechanical force for function. A ch...

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Detalles Bibliográficos
Autores principales:	Qin, Zhaoping, Voorhees, John J, Fisher, Gary J, Quan, Taihao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326925/ https://www.ncbi.nlm.nih.gov/pubmed/25201474 http://dx.doi.org/10.1111/acel.12265

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