In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice

In mtDNA mutator mice, mtDNA mutations accumulate leading to a rapidly aging phenotype. However, there is little evidence of oxidative damage to tissues, and when analyzed ex vivo, no change in production of the reactive oxygen species (ROS) superoxide and hydrogen peroxide by mitochondria has been...

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Detalles Bibliográficos
Autores principales: Logan, Angela, Shabalina, Irina G, Prime, Tracy A, Rogatti, Sebastian, Kalinovich, Anastasia V, Hartley, Richard C, Budd, Ralph C, Cannon, Barbara, Murphy, Michael P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Short Takes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326952/
https://www.ncbi.nlm.nih.gov/pubmed/24621297
http://dx.doi.org/10.1111/acel.12212

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