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Terahertz in-line digital holography of human hepatocellular carcinoma tissue
Terahertz waves provide a better contrast in imaging soft biomedical tissues than X-rays, and unlike X-rays, they cause no ionisation damage, making them a good option for biomedical imaging. Terahertz absorption imaging has conventionally been used for cancer diagnosis. However, the absorption prop...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326957/ https://www.ncbi.nlm.nih.gov/pubmed/25676705 http://dx.doi.org/10.1038/srep08445 |
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author | Rong, Lu Latychevskaia, Tatiana Chen, Chunhai Wang, Dayong Yu, Zhengping Zhou, Xun Li, Zeyu Huang, Haochong Wang, Yunxin Zhou, Zhou |
author_facet | Rong, Lu Latychevskaia, Tatiana Chen, Chunhai Wang, Dayong Yu, Zhengping Zhou, Xun Li, Zeyu Huang, Haochong Wang, Yunxin Zhou, Zhou |
author_sort | Rong, Lu |
collection | PubMed |
description | Terahertz waves provide a better contrast in imaging soft biomedical tissues than X-rays, and unlike X-rays, they cause no ionisation damage, making them a good option for biomedical imaging. Terahertz absorption imaging has conventionally been used for cancer diagnosis. However, the absorption properties of a cancerous sample are influenced by two opposing factors: an increase in absorption due to a higher degree of hydration and a decrease in absorption due to structural changes. It is therefore difficult to diagnose cancer from an absorption image. Phase imaging can thus be critical for diagnostics. We demonstrate imaging of the absorption and phase-shift distributions of 3.2 mm × 2.3 mm × 30-μm-thick human hepatocellular carcinoma tissue by continuous-wave terahertz digital in-line holography. The acquisition time of a few seconds for a single in-line hologram is much shorter than that of other terahertz diagnostic techniques, and future detectors will allow acquisition of meaningful holograms without sample dehydration. The resolution of the reconstructions was enhanced by sub-pixel shifting and extrapolation. Another advantage of this technique is its relaxed minimal sample size limitation. The fibrosis indicated in the phase distribution demonstrates the potential of terahertz holographic imaging to obtain a more objective, early diagnosis of cancer. |
format | Online Article Text |
id | pubmed-4326957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-43269572015-04-08 Terahertz in-line digital holography of human hepatocellular carcinoma tissue Rong, Lu Latychevskaia, Tatiana Chen, Chunhai Wang, Dayong Yu, Zhengping Zhou, Xun Li, Zeyu Huang, Haochong Wang, Yunxin Zhou, Zhou Sci Rep Article Terahertz waves provide a better contrast in imaging soft biomedical tissues than X-rays, and unlike X-rays, they cause no ionisation damage, making them a good option for biomedical imaging. Terahertz absorption imaging has conventionally been used for cancer diagnosis. However, the absorption properties of a cancerous sample are influenced by two opposing factors: an increase in absorption due to a higher degree of hydration and a decrease in absorption due to structural changes. It is therefore difficult to diagnose cancer from an absorption image. Phase imaging can thus be critical for diagnostics. We demonstrate imaging of the absorption and phase-shift distributions of 3.2 mm × 2.3 mm × 30-μm-thick human hepatocellular carcinoma tissue by continuous-wave terahertz digital in-line holography. The acquisition time of a few seconds for a single in-line hologram is much shorter than that of other terahertz diagnostic techniques, and future detectors will allow acquisition of meaningful holograms without sample dehydration. The resolution of the reconstructions was enhanced by sub-pixel shifting and extrapolation. Another advantage of this technique is its relaxed minimal sample size limitation. The fibrosis indicated in the phase distribution demonstrates the potential of terahertz holographic imaging to obtain a more objective, early diagnosis of cancer. Nature Publishing Group 2015-02-13 /pmc/articles/PMC4326957/ /pubmed/25676705 http://dx.doi.org/10.1038/srep08445 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Rong, Lu Latychevskaia, Tatiana Chen, Chunhai Wang, Dayong Yu, Zhengping Zhou, Xun Li, Zeyu Huang, Haochong Wang, Yunxin Zhou, Zhou Terahertz in-line digital holography of human hepatocellular carcinoma tissue |
title | Terahertz in-line digital holography of human hepatocellular carcinoma tissue |
title_full | Terahertz in-line digital holography of human hepatocellular carcinoma tissue |
title_fullStr | Terahertz in-line digital holography of human hepatocellular carcinoma tissue |
title_full_unstemmed | Terahertz in-line digital holography of human hepatocellular carcinoma tissue |
title_short | Terahertz in-line digital holography of human hepatocellular carcinoma tissue |
title_sort | terahertz in-line digital holography of human hepatocellular carcinoma tissue |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326957/ https://www.ncbi.nlm.nih.gov/pubmed/25676705 http://dx.doi.org/10.1038/srep08445 |
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