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A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema

PURPOSE: We report a case of laryngeal edema associated with the Vogt-Koyanagi-Harada (VKH) syndrome. PATIENT AND METHODS: A 32-year-old African-American female presented with a 12-day prodrome, including headache, tinnitus and shortness of breath, which preceded sudden photophobia and bilateral vis...

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Autores principales: Mantopoulos, Dimosthenis, deSilva, Brad W., Cebulla, Colleen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327331/
https://www.ncbi.nlm.nih.gov/pubmed/25759662
http://dx.doi.org/10.1159/000369003
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author Mantopoulos, Dimosthenis
deSilva, Brad W.
Cebulla, Colleen M.
author_facet Mantopoulos, Dimosthenis
deSilva, Brad W.
Cebulla, Colleen M.
author_sort Mantopoulos, Dimosthenis
collection PubMed
description PURPOSE: We report a case of laryngeal edema associated with the Vogt-Koyanagi-Harada (VKH) syndrome. PATIENT AND METHODS: A 32-year-old African-American female presented with a 12-day prodrome, including headache, tinnitus and shortness of breath, which preceded sudden photophobia and bilateral visual loss. Examination and clinical testing were most consistent with VKH, and the patient improved with intravenous methylprednisolone therapy. RESULTS: The patient had persistent dyspnea, which was out of proportion to chest CT findings and which was exacerbated during a recurrence of VKH. Flexible fiberoptic laryngoscopy with stroboscopy revealed diffuse laryngeal edema. Symptoms were alleviated with breathing exercises. CONCLUSIONS: Several autoimmune diseases may cause diffuse laryngeal edema. In this case, VKH was associated with the patient's glottic edema and dyspnea. We recommend that laryngeal edema be considered in the differential diagnosis for patients with dyspnea and VKH.
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spelling pubmed-43273312015-03-10 A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema Mantopoulos, Dimosthenis deSilva, Brad W. Cebulla, Colleen M. Case Rep Ophthalmol Published online: November, 2014 PURPOSE: We report a case of laryngeal edema associated with the Vogt-Koyanagi-Harada (VKH) syndrome. PATIENT AND METHODS: A 32-year-old African-American female presented with a 12-day prodrome, including headache, tinnitus and shortness of breath, which preceded sudden photophobia and bilateral visual loss. Examination and clinical testing were most consistent with VKH, and the patient improved with intravenous methylprednisolone therapy. RESULTS: The patient had persistent dyspnea, which was out of proportion to chest CT findings and which was exacerbated during a recurrence of VKH. Flexible fiberoptic laryngoscopy with stroboscopy revealed diffuse laryngeal edema. Symptoms were alleviated with breathing exercises. CONCLUSIONS: Several autoimmune diseases may cause diffuse laryngeal edema. In this case, VKH was associated with the patient's glottic edema and dyspnea. We recommend that laryngeal edema be considered in the differential diagnosis for patients with dyspnea and VKH. S. Karger AG 2014-11-07 /pmc/articles/PMC4327331/ /pubmed/25759662 http://dx.doi.org/10.1159/000369003 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: November, 2014
Mantopoulos, Dimosthenis
deSilva, Brad W.
Cebulla, Colleen M.
A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema
title A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema
title_full A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema
title_fullStr A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema
title_full_unstemmed A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema
title_short A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema
title_sort case of vogt-koyanagi-harada syndrome with persistent dyspnea secondary to laryngeal edema
topic Published online: November, 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327331/
https://www.ncbi.nlm.nih.gov/pubmed/25759662
http://dx.doi.org/10.1159/000369003
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