Cargando…

Emergence of a STAT3 mutated NK clone in LGL leukemia

Large granular lymphocyte (LGL) leukemia is a chronic clonal lymphoproliferative disorder. Here, a T-LGL leukemia patient developed NK-LGL leukemia with residual leukemic T-LGL. TCRVβ usage and CDR3 sequence drifts were observed with disease progression. A STAT3 S614R mutation was identified in NK b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Yiyi, Olson, Thomas L., Nyland, Susan B., Feith, David J., Loughran, Thomas P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327758/ https://www.ncbi.nlm.nih.gov/pubmed/25709890 http://dx.doi.org/10.1016/j.lrr.2014.12.001

Ejemplares similares

Retrovirus insertion site analysis of LGL leukemia patient genomes
por: Li, Weiling, et al.
Publicado: (2019)

LGL leukemia patients exhibit substantial protective humoral responses following SARS‐CoV‐2 vaccination
por: Cheon, Heejin, et al.
Publicado: (2022)

STAT3 mutation impacts biological and clinical features of T-LGL leukemia
por: Teramo, Antonella, et al.
Publicado: (2017)

STAT3 and STAT5B Mutations in T/NK-Cell Chronic Lymphoproliferative Disorders of Large Granular Lymphocytes (LGL): Association with Disease Features
por: Muñoz-García, Noemí, et al.
Publicado: (2020)

Are T-LGL Leukemia and NK-Chronic Lymphoproliferative Disorder Really Two Distinct Diseases?
por: Zambello, Renato, et al.
Publicado: (2014)

Cyclophosphamide as a first-line therapy in LGL leukemia
por: Moignet, A, et al.
Publicado: (2014)

STAT5b in LGL leukemia – a novel therapeutic target?
por: Rajala, Hanna L. M., et al.
Publicado: (2013)

Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations
por: Olson, Kristine C., et al.
Publicado: (2020)

A guilt-by-association mutation network in LGL leukemia
por: Andersson, Emma I., et al.
Publicado: (2017)

A case report of T-LGL leukemia-associated pure red cell aplasia harboring STAT3, TNFAIP3, and KMT2D mutation
por: Shen, Meixiao
Publicado: (2023)

Toward a Better Classification System for NK-LGL Disorders
por: Drillet, Gaëlle, et al.
Publicado: (2022)

Small-Sized Clone of T Cells in Multiple Myeloma Patient after Auto-SCT: T-LGL Leukemia Type or Clonal T-Cell Aberration?
por: Mele, Giuseppe, et al.
Publicado: (2013)

A case of LGL leukemia with paucity of erythropoiesis
por: Razavi, Habib M.
Publicado: (2020)

Dysregulation of the IFN-γ-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia
por: Kulling, Paige M., et al.
Publicado: (2018)

Restoring the Long Noncoding RNA MEG3 Indicates a Potential Role for JAK-STAT Signaling in Chronic Myeloid Leukemia
por: Olson, Thomas L., et al.
Publicado: (2018)

Case Report: mRNA vaccination-mediated STAT3 overactivation with agranulocytosis and clonal T-LGL expansion
por: Hirsiger, Julia R., et al.
Publicado: (2023)

BLNK mutation associated with T-cell LGL leukemia and autoimmune diseases: Case report in hematology
por: Fouquet, Guillemette, et al.
Publicado: (2022)

Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia
por: Savola, Paula, et al.
Publicado: (2018)

Cyclophosphamide induces durable molecular and clinical responses in patients with relapsed T-LGL leukemia
por: Braunstein, Zachary, et al.
Publicado: (2022)

T-cell large granular lymphocytic (LGL) leukemia consists of CD4(+)/CD8(dim) and CD4(-)/CD8(+) LGL populations in association with immune thrombocytopenia, autoimmune neutropenia, and monoclonal B-cell lymphocytosis
por: Kuwahara, Naoya, et al.
Publicado: (2019)

Successful treatment of cerebral aspergillosis: case report of a patient with T-cell large granular lymphocytic leukemia (T-LGL)
por: Turki, Amin T., et al.
Publicado: (2017)

STAT5B(N642H) drives transformation of NKT cells: a novel mouse model for CD56(+) T-LGL leukemia
por: Klein, Klara, et al.
Publicado: (2019)

Inhibition of glioblastoma malignancy by Lgl1
por: Gont, Alexander, et al.
Publicado: (2014)

Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation
por: Wang, T. Tiffany, et al.
Publicado: (2020)

Intersection Between Large Granular Lymphocyte Leukemia and Rheumatoid Arthritis
por: Moosic, Katharine B., et al.
Publicado: (2022)

Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation
por: Andersson, E I, et al.
Publicado: (2013)

dbLGL: an online leukemia gene and literature database for the retrospective comparison of adult and childhood leukemia genetics with literature evidence
por: Liu, Yining, et al.
Publicado: (2018)

Involvement of Lgl and Mahjong/VprBP in Cell Competition
por: Tamori, Yoichiro, et al.
Publicado: (2010)

INVOLVEMENT OF KRAS G12A MUTATION IN THE IL-2-INDEPENDENT GROWTH OF A HUMAN T-LGL LEUKEMIA CELL LINE, PLT-2
por: MIZUTANI, NAOKI, et al.
Publicado: (2012)

STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia
por: Doshi, Ushma A, et al.
Publicado: (2017)

miR-181a is a novel player in the STAT3-mediated survival network of TCRαβ+ CD8+ T large granular lymphocyte leukemia
por: Assmann, Jorn L. J. C., et al.
Publicado: (2021)

Lgl1 Is Required for Olfaction and Development of Olfactory Bulb in Mice
por: Li, Zhenzu, et al.
Publicado: (2016)

Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex
por: Yamashita, Kazunari, et al.
Publicado: (2015)

Metronomic regimen as an effective treatment for aggressive T-LGL leukemia with central nervous system infiltration: clinical experience and review of literature
por: Liu, Yun, et al.
Publicado: (2017)

Florid Pulmonary Mycobacterium avium-intracellulare Infection in a Patient With Large Granular Lymphocytic (LGL) Leukemia on Chronic Cyclophosphamide
por: Kojadinovic, Arsenije, et al.
Publicado: (2021)

Notch signals modulate lgl mediated tumorigenesis by the activation of JNK signaling
por: Paul, Maimuna Sali, et al.
Publicado: (2018)

penner/lgl2 is required for the integrity of the photoreceptor layer in the zebrafish retina
por: Kujawski, Satu, et al.
Publicado: (2019)

Correction: Lgl1 Is Required for Olfaction and Development of Olfactory Bulb in Mice
por: Li, Zhenzu, et al.
Publicado: (2017)

STAT3 Dysregulation in Mature T and NK Cell Lymphomas
por: Seffens, Angelina, et al.
Publicado: (2019)

Attack of the clones: An NK cell origins story
por: Caporale, Joseph R., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_182gg7boh85nqj9ueukkco4kdl