An intensive approach to treatment for older patients with relapsed isolated NPM1 mutated AML

We present a short case series of elderly patients with NK-AML and isolated NPM1 mutation who were treated with intensive chemotherapy, achieving significant CRs multiple times on reinduction, even with a single course.We hope to highlight the NPM1 as a molecular marker in elderly for consideration...

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Detalles Bibliográficos
Autores principales: Dukka, Srivasavi, Bowen, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327759/
https://www.ncbi.nlm.nih.gov/pubmed/25709893
http://dx.doi.org/10.1016/j.lrr.2015.01.001
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author Dukka, Srivasavi
Bowen, David T.
author_facet Dukka, Srivasavi
Bowen, David T.
author_sort Dukka, Srivasavi
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description We present a short case series of elderly patients with NK-AML and isolated NPM1 mutation who were treated with intensive chemotherapy, achieving significant CRs multiple times on reinduction, even with a single course.We hope to highlight the NPM1 as a molecular marker in elderly for consideration of aggressive treatment, even if abridged, as this subset may achieve a durable, good quality responses at diagnosis or subsequent relapses.
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spelling pubmed-43277592015-02-23 An intensive approach to treatment for older patients with relapsed isolated NPM1 mutated AML Dukka, Srivasavi Bowen, David T. Leuk Res Rep Article We present a short case series of elderly patients with NK-AML and isolated NPM1 mutation who were treated with intensive chemotherapy, achieving significant CRs multiple times on reinduction, even with a single course.We hope to highlight the NPM1 as a molecular marker in elderly for consideration of aggressive treatment, even if abridged, as this subset may achieve a durable, good quality responses at diagnosis or subsequent relapses. Elsevier 2015-01-16 /pmc/articles/PMC4327759/ /pubmed/25709893 http://dx.doi.org/10.1016/j.lrr.2015.01.001 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Dukka, Srivasavi
Bowen, David T.
An intensive approach to treatment for older patients with relapsed isolated NPM1 mutated AML
title An intensive approach to treatment for older patients with relapsed isolated NPM1 mutated AML
title_full An intensive approach to treatment for older patients with relapsed isolated NPM1 mutated AML
title_fullStr An intensive approach to treatment for older patients with relapsed isolated NPM1 mutated AML
title_full_unstemmed An intensive approach to treatment for older patients with relapsed isolated NPM1 mutated AML
title_short An intensive approach to treatment for older patients with relapsed isolated NPM1 mutated AML
title_sort intensive approach to treatment for older patients with relapsed isolated npm1 mutated aml
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327759/
https://www.ncbi.nlm.nih.gov/pubmed/25709893
http://dx.doi.org/10.1016/j.lrr.2015.01.001
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