Steroids and Sesquiterpenes From Cultures of the Fungus Phellinus igniarius

Two new steroids, 3α,17α,19,20-tetrahydroxy-4α-methylpregn-8-ene (1) and 3α,12α,17α,20-tetrahydroxy-4α-methylpregn-8-ene (2) and three new sesquiterpenoids, 12-hydroxy-α-cadinol (3), 3α,12-dihydroxy-δ-cadinol (4), and 3α,6α-dihydroxyspiroax-4-ene (5), have been isolated from cultures of the fungus P...

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Autores principales: Yin, Rong-Hua, Zhao, Zhen-Zhu, Ji, Xu, Dong, Ze-Jun, Li, Zheng-Hui, Feng, Tao, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327997/
https://www.ncbi.nlm.nih.gov/pubmed/25432445
http://dx.doi.org/10.1007/s13659-014-0045-z
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author Yin, Rong-Hua
Zhao, Zhen-Zhu
Ji, Xu
Dong, Ze-Jun
Li, Zheng-Hui
Feng, Tao
Liu, Ji-Kai
author_facet Yin, Rong-Hua
Zhao, Zhen-Zhu
Ji, Xu
Dong, Ze-Jun
Li, Zheng-Hui
Feng, Tao
Liu, Ji-Kai
author_sort Yin, Rong-Hua
collection PubMed
description Two new steroids, 3α,17α,19,20-tetrahydroxy-4α-methylpregn-8-ene (1) and 3α,12α,17α,20-tetrahydroxy-4α-methylpregn-8-ene (2) and three new sesquiterpenoids, 12-hydroxy-α-cadinol (3), 3α,12-dihydroxy-δ-cadinol (4), and 3α,6α-dihydroxyspiroax-4-ene (5), have been isolated from cultures of the fungus Phellinus igniarius. Their structures were characterized based on extensive spectroscopic data. In preliminary in vitro assays, compounds 3 and 4 exhibited the vascular-activities against phenylephrine-induced vasoconstriction with the relaxing rates of 11.0 % and 7.0 % at 3 × 10(−4) M, respectively. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0045-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-43279972015-02-19 Steroids and Sesquiterpenes From Cultures of the Fungus Phellinus igniarius Yin, Rong-Hua Zhao, Zhen-Zhu Ji, Xu Dong, Ze-Jun Li, Zheng-Hui Feng, Tao Liu, Ji-Kai Nat Prod Bioprospect Original Article Two new steroids, 3α,17α,19,20-tetrahydroxy-4α-methylpregn-8-ene (1) and 3α,12α,17α,20-tetrahydroxy-4α-methylpregn-8-ene (2) and three new sesquiterpenoids, 12-hydroxy-α-cadinol (3), 3α,12-dihydroxy-δ-cadinol (4), and 3α,6α-dihydroxyspiroax-4-ene (5), have been isolated from cultures of the fungus Phellinus igniarius. Their structures were characterized based on extensive spectroscopic data. In preliminary in vitro assays, compounds 3 and 4 exhibited the vascular-activities against phenylephrine-induced vasoconstriction with the relaxing rates of 11.0 % and 7.0 % at 3 × 10(−4) M, respectively. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-014-0045-z) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2014-11-29 /pmc/articles/PMC4327997/ /pubmed/25432445 http://dx.doi.org/10.1007/s13659-014-0045-z Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ This article is published under license to BioMed Central Ltd.Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Yin, Rong-Hua
Zhao, Zhen-Zhu
Ji, Xu
Dong, Ze-Jun
Li, Zheng-Hui
Feng, Tao
Liu, Ji-Kai
Steroids and Sesquiterpenes From Cultures of the Fungus Phellinus igniarius
title Steroids and Sesquiterpenes From Cultures of the Fungus Phellinus igniarius
title_full Steroids and Sesquiterpenes From Cultures of the Fungus Phellinus igniarius
title_fullStr Steroids and Sesquiterpenes From Cultures of the Fungus Phellinus igniarius
title_full_unstemmed Steroids and Sesquiterpenes From Cultures of the Fungus Phellinus igniarius
title_short Steroids and Sesquiterpenes From Cultures of the Fungus Phellinus igniarius
title_sort steroids and sesquiterpenes from cultures of the fungus phellinus igniarius
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327997/
https://www.ncbi.nlm.nih.gov/pubmed/25432445
http://dx.doi.org/10.1007/s13659-014-0045-z
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