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Understanding the colon cancer stem cells and perspectives on treatment
An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor initiation, growth, invasion and metastasis are promoted by CSCs. An important reason for the widesp...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328053/ https://www.ncbi.nlm.nih.gov/pubmed/25685060 http://dx.doi.org/10.1186/s12935-015-0163-7 |
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author | Garza-Treviño, Elsa N Said-Fernández, Salvador L Martínez-Rodríguez, Herminia G |
author_facet | Garza-Treviño, Elsa N Said-Fernández, Salvador L Martínez-Rodríguez, Herminia G |
author_sort | Garza-Treviño, Elsa N |
collection | PubMed |
description | An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor initiation, growth, invasion and metastasis are promoted by CSCs. An important reason for the widespread interest in the CSC model is that it can comprehensibly explain essential and poorly understood clinical events, such as therapy resistance, minimal residual disease, and tumor recurrence. This review discusses the recent advances in colon cancer stem cell research, the genes responsible for CSC chemoresistance, and new therapies against CSCs. |
format | Online Article Text |
id | pubmed-4328053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43280532015-02-15 Understanding the colon cancer stem cells and perspectives on treatment Garza-Treviño, Elsa N Said-Fernández, Salvador L Martínez-Rodríguez, Herminia G Cancer Cell Int Review An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor initiation, growth, invasion and metastasis are promoted by CSCs. An important reason for the widespread interest in the CSC model is that it can comprehensibly explain essential and poorly understood clinical events, such as therapy resistance, minimal residual disease, and tumor recurrence. This review discusses the recent advances in colon cancer stem cell research, the genes responsible for CSC chemoresistance, and new therapies against CSCs. BioMed Central 2015-01-28 /pmc/articles/PMC4328053/ /pubmed/25685060 http://dx.doi.org/10.1186/s12935-015-0163-7 Text en © Garza-Treviño et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Garza-Treviño, Elsa N Said-Fernández, Salvador L Martínez-Rodríguez, Herminia G Understanding the colon cancer stem cells and perspectives on treatment |
title | Understanding the colon cancer stem cells and perspectives on treatment |
title_full | Understanding the colon cancer stem cells and perspectives on treatment |
title_fullStr | Understanding the colon cancer stem cells and perspectives on treatment |
title_full_unstemmed | Understanding the colon cancer stem cells and perspectives on treatment |
title_short | Understanding the colon cancer stem cells and perspectives on treatment |
title_sort | understanding the colon cancer stem cells and perspectives on treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328053/ https://www.ncbi.nlm.nih.gov/pubmed/25685060 http://dx.doi.org/10.1186/s12935-015-0163-7 |
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