Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

Mycobacterium tuberculosis (MTB) remains a major challenge to global health made worse by the spread of multidrug resistance. We therefore examined whether stimulating intracellular killing of mycobacteria through pharmacological enhancement of macroautophagy might provide a novel therapeutic strate...

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Detalles Bibliográficos
Autores principales: Schiebler, Mark, Brown, Karen, Hegyi, Krisztina, Newton, Sandra M, Renna, Maurizio, Hepburn, Lucy, Klapholz, Catherine, Coulter, Sarah, Obregón-Henao, Andres, Henao Tamayo, Marcela, Basaraba, Randall, Kampmann, Beate, Henry, Katherine M, Burgon, Joseph, Renshaw, Stephen A, Fleming, Angeleen, Kay, Robert R, Anderson, Karen E, Hawkins, Phillip T, Ordway, Diane J, Rubinsztein, David C, Floto, Rodrigo Andres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328644/
https://www.ncbi.nlm.nih.gov/pubmed/25535254
http://dx.doi.org/10.15252/emmm.201404137

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