An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

The β-site amyloid precursor protein cleaving enzyme-1 (BACE1), an essential protease for the generation of amyloid-β (Aβ) peptide, is a major drug target for Alzheimer's disease (AD). However, there is a concern that inhibiting BACE1 could also affect several physiological functions. Here, we...

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Detalles Bibliográficos
Autores principales: Kizuka, Yasuhiko, Kitazume, Shinobu, Fujinawa, Reiko, Saito, Takashi, Iwata, Nobuhisa, Saido, Takaomi C, Nakano, Miyako, Yamaguchi, Yoshiki, Hashimoto, Yasuhiro, Staufenbiel, Matthias, Hatsuta, Hiroyuki, Murayama, Shigeo, Manya, Hiroshi, Endo, Tamao, Taniguchi, Naoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328647/
https://www.ncbi.nlm.nih.gov/pubmed/25592972
http://dx.doi.org/10.15252/emmm.201404438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328647/
https://www.ncbi.nlm.nih.gov/pubmed/25592972
http://dx.doi.org/10.15252/emmm.201404438

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