Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

Alzheimer's disease (AD) is associated with peripheral metabolic disorders. Clinical/epidemiological data indicate increased risk of diabetes in AD patients. Here, we show that intracerebroventricular infusion of AD-associated Aβ oligomers (AβOs) in mice triggered peripheral glucose intolerance...

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Detalles Bibliográficos
Autores principales: Clarke, Julia R, Lyra e Silva, Natalia M, Figueiredo, Claudia P, Frozza, Rudimar L, Ledo, Jose H, Beckman, Danielle, Katashima, Carlos K, Razolli, Daniela, Carvalho, Bruno M, Frazão, Renata, Silveira, Marina A, Ribeiro, Felipe C, Bomfim, Theresa R, Neves, Fernanda S, Klein, William L, Medeiros, Rodrigo, LaFerla, Frank M, Carvalheira, Jose B, Saad, Mario J, Munoz, Douglas P, Velloso, Licio A, Ferreira, Sergio T, De Felice, Fernanda G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328648/
https://www.ncbi.nlm.nih.gov/pubmed/25617315
http://dx.doi.org/10.15252/emmm.201404183

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