Cargando…

Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity

BACKGROUND: The impact of dairy intake on cardiometabolic risk factors associated with metabolic syndrome (MetS) needs further research. OBJECTIVE: To investigate the impact of milk consumption on a wide array of cardiometabolic risk factors associated with MetS (blood lipids, cholesterol homeostasi...

Descripción completa

Detalles Bibliográficos
Autores principales: Drouin-Chartier, Jean-Philippe, Gagnon, Josée, Labonté, Marie-Ève, Desroches, Sophie, Charest, Amélie, Grenier, Geneviève, Dodin, Sylvie, Lemieux, Simone, Couture, Patrick, Lamarche, Benoît
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328687/
https://www.ncbi.nlm.nih.gov/pubmed/25604722
http://dx.doi.org/10.1186/1475-2891-14-12
_version_ 1782357318285918208
author Drouin-Chartier, Jean-Philippe
Gagnon, Josée
Labonté, Marie-Ève
Desroches, Sophie
Charest, Amélie
Grenier, Geneviève
Dodin, Sylvie
Lemieux, Simone
Couture, Patrick
Lamarche, Benoît
author_facet Drouin-Chartier, Jean-Philippe
Gagnon, Josée
Labonté, Marie-Ève
Desroches, Sophie
Charest, Amélie
Grenier, Geneviève
Dodin, Sylvie
Lemieux, Simone
Couture, Patrick
Lamarche, Benoît
author_sort Drouin-Chartier, Jean-Philippe
collection PubMed
description BACKGROUND: The impact of dairy intake on cardiometabolic risk factors associated with metabolic syndrome (MetS) needs further research. OBJECTIVE: To investigate the impact of milk consumption on a wide array of cardiometabolic risk factors associated with MetS (blood lipids, cholesterol homeostasis, glucose homeostasis, systemic inflammation, blood pressure, endothelial function) in postmenopausal women with abdominal obesity. METHODS: In this randomized, crossover study, 27 women with abdominal obesity consumed two 6-week diets based on the National Cholesterol Education Program (NCEP), one with 3.2 servings/d of 2% fat milk per 2000 kcal (MILK) and one without milk or other dairy (NCEP). The macronutrient composition of both diets was comparable (55% carbohydrates, 15% proteins, 30% fat and 10% saturated fat). RESULTS: The MILK diet had no significant effect on LDL-C, triglycerides, LDL size, CRP and cell adhesion molecule concentrations and on indicators of insulin sensitivity. The MILK diet reduced HDL-C, adiponectin, endothelin and fasting glucose levels as well blood pressure (all P ≤ 0.01), but those changes were comparable to those seen with the NCEP milk-free diet (all between-diet P ≥ 0.07). Finally, the MILK diet was associated with lower VLDL apolipoprotein B fractional catabolic rate (−13.4%; P = 0.04) and plasma sterol concentrations (−12.0%; P = 0.04) compared with the control NCEP milk-free diet. CONCLUSIONS: These data suggest that short-term consumption of low fat milk in the context of a prudent NCEP diet has no favorable nor deleterious effect on cardiometabolic risk factors associated with MetS in postmenopausal women with abdominal obesity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1475-2891-14-12) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-4328687
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-43286872015-02-15 Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity Drouin-Chartier, Jean-Philippe Gagnon, Josée Labonté, Marie-Ève Desroches, Sophie Charest, Amélie Grenier, Geneviève Dodin, Sylvie Lemieux, Simone Couture, Patrick Lamarche, Benoît Nutr J Research BACKGROUND: The impact of dairy intake on cardiometabolic risk factors associated with metabolic syndrome (MetS) needs further research. OBJECTIVE: To investigate the impact of milk consumption on a wide array of cardiometabolic risk factors associated with MetS (blood lipids, cholesterol homeostasis, glucose homeostasis, systemic inflammation, blood pressure, endothelial function) in postmenopausal women with abdominal obesity. METHODS: In this randomized, crossover study, 27 women with abdominal obesity consumed two 6-week diets based on the National Cholesterol Education Program (NCEP), one with 3.2 servings/d of 2% fat milk per 2000 kcal (MILK) and one without milk or other dairy (NCEP). The macronutrient composition of both diets was comparable (55% carbohydrates, 15% proteins, 30% fat and 10% saturated fat). RESULTS: The MILK diet had no significant effect on LDL-C, triglycerides, LDL size, CRP and cell adhesion molecule concentrations and on indicators of insulin sensitivity. The MILK diet reduced HDL-C, adiponectin, endothelin and fasting glucose levels as well blood pressure (all P ≤ 0.01), but those changes were comparable to those seen with the NCEP milk-free diet (all between-diet P ≥ 0.07). Finally, the MILK diet was associated with lower VLDL apolipoprotein B fractional catabolic rate (−13.4%; P = 0.04) and plasma sterol concentrations (−12.0%; P = 0.04) compared with the control NCEP milk-free diet. CONCLUSIONS: These data suggest that short-term consumption of low fat milk in the context of a prudent NCEP diet has no favorable nor deleterious effect on cardiometabolic risk factors associated with MetS in postmenopausal women with abdominal obesity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1475-2891-14-12) contains supplementary material, which is available to authorized users. BioMed Central 2015-01-21 /pmc/articles/PMC4328687/ /pubmed/25604722 http://dx.doi.org/10.1186/1475-2891-14-12 Text en © Drouin-Chartier et al.; licensee BioMed Central. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Drouin-Chartier, Jean-Philippe
Gagnon, Josée
Labonté, Marie-Ève
Desroches, Sophie
Charest, Amélie
Grenier, Geneviève
Dodin, Sylvie
Lemieux, Simone
Couture, Patrick
Lamarche, Benoît
Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity
title Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity
title_full Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity
title_fullStr Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity
title_full_unstemmed Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity
title_short Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity
title_sort impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328687/
https://www.ncbi.nlm.nih.gov/pubmed/25604722
http://dx.doi.org/10.1186/1475-2891-14-12
work_keys_str_mv AT drouinchartierjeanphilippe impactofmilkconsumptiononcardiometabolicriskinpostmenopausalwomenwithabdominalobesity
AT gagnonjosee impactofmilkconsumptiononcardiometabolicriskinpostmenopausalwomenwithabdominalobesity
AT labontemarieeve impactofmilkconsumptiononcardiometabolicriskinpostmenopausalwomenwithabdominalobesity
AT desrochessophie impactofmilkconsumptiononcardiometabolicriskinpostmenopausalwomenwithabdominalobesity
AT charestamelie impactofmilkconsumptiononcardiometabolicriskinpostmenopausalwomenwithabdominalobesity
AT greniergenevieve impactofmilkconsumptiononcardiometabolicriskinpostmenopausalwomenwithabdominalobesity
AT dodinsylvie impactofmilkconsumptiononcardiometabolicriskinpostmenopausalwomenwithabdominalobesity
AT lemieuxsimone impactofmilkconsumptiononcardiometabolicriskinpostmenopausalwomenwithabdominalobesity
AT couturepatrick impactofmilkconsumptiononcardiometabolicriskinpostmenopausalwomenwithabdominalobesity
AT lamarchebenoit impactofmilkconsumptiononcardiometabolicriskinpostmenopausalwomenwithabdominalobesity