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Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity
BACKGROUND: The impact of dairy intake on cardiometabolic risk factors associated with metabolic syndrome (MetS) needs further research. OBJECTIVE: To investigate the impact of milk consumption on a wide array of cardiometabolic risk factors associated with MetS (blood lipids, cholesterol homeostasi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328687/ https://www.ncbi.nlm.nih.gov/pubmed/25604722 http://dx.doi.org/10.1186/1475-2891-14-12 |
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author | Drouin-Chartier, Jean-Philippe Gagnon, Josée Labonté, Marie-Ève Desroches, Sophie Charest, Amélie Grenier, Geneviève Dodin, Sylvie Lemieux, Simone Couture, Patrick Lamarche, Benoît |
author_facet | Drouin-Chartier, Jean-Philippe Gagnon, Josée Labonté, Marie-Ève Desroches, Sophie Charest, Amélie Grenier, Geneviève Dodin, Sylvie Lemieux, Simone Couture, Patrick Lamarche, Benoît |
author_sort | Drouin-Chartier, Jean-Philippe |
collection | PubMed |
description | BACKGROUND: The impact of dairy intake on cardiometabolic risk factors associated with metabolic syndrome (MetS) needs further research. OBJECTIVE: To investigate the impact of milk consumption on a wide array of cardiometabolic risk factors associated with MetS (blood lipids, cholesterol homeostasis, glucose homeostasis, systemic inflammation, blood pressure, endothelial function) in postmenopausal women with abdominal obesity. METHODS: In this randomized, crossover study, 27 women with abdominal obesity consumed two 6-week diets based on the National Cholesterol Education Program (NCEP), one with 3.2 servings/d of 2% fat milk per 2000 kcal (MILK) and one without milk or other dairy (NCEP). The macronutrient composition of both diets was comparable (55% carbohydrates, 15% proteins, 30% fat and 10% saturated fat). RESULTS: The MILK diet had no significant effect on LDL-C, triglycerides, LDL size, CRP and cell adhesion molecule concentrations and on indicators of insulin sensitivity. The MILK diet reduced HDL-C, adiponectin, endothelin and fasting glucose levels as well blood pressure (all P ≤ 0.01), but those changes were comparable to those seen with the NCEP milk-free diet (all between-diet P ≥ 0.07). Finally, the MILK diet was associated with lower VLDL apolipoprotein B fractional catabolic rate (−13.4%; P = 0.04) and plasma sterol concentrations (−12.0%; P = 0.04) compared with the control NCEP milk-free diet. CONCLUSIONS: These data suggest that short-term consumption of low fat milk in the context of a prudent NCEP diet has no favorable nor deleterious effect on cardiometabolic risk factors associated with MetS in postmenopausal women with abdominal obesity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1475-2891-14-12) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4328687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43286872015-02-15 Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity Drouin-Chartier, Jean-Philippe Gagnon, Josée Labonté, Marie-Ève Desroches, Sophie Charest, Amélie Grenier, Geneviève Dodin, Sylvie Lemieux, Simone Couture, Patrick Lamarche, Benoît Nutr J Research BACKGROUND: The impact of dairy intake on cardiometabolic risk factors associated with metabolic syndrome (MetS) needs further research. OBJECTIVE: To investigate the impact of milk consumption on a wide array of cardiometabolic risk factors associated with MetS (blood lipids, cholesterol homeostasis, glucose homeostasis, systemic inflammation, blood pressure, endothelial function) in postmenopausal women with abdominal obesity. METHODS: In this randomized, crossover study, 27 women with abdominal obesity consumed two 6-week diets based on the National Cholesterol Education Program (NCEP), one with 3.2 servings/d of 2% fat milk per 2000 kcal (MILK) and one without milk or other dairy (NCEP). The macronutrient composition of both diets was comparable (55% carbohydrates, 15% proteins, 30% fat and 10% saturated fat). RESULTS: The MILK diet had no significant effect on LDL-C, triglycerides, LDL size, CRP and cell adhesion molecule concentrations and on indicators of insulin sensitivity. The MILK diet reduced HDL-C, adiponectin, endothelin and fasting glucose levels as well blood pressure (all P ≤ 0.01), but those changes were comparable to those seen with the NCEP milk-free diet (all between-diet P ≥ 0.07). Finally, the MILK diet was associated with lower VLDL apolipoprotein B fractional catabolic rate (−13.4%; P = 0.04) and plasma sterol concentrations (−12.0%; P = 0.04) compared with the control NCEP milk-free diet. CONCLUSIONS: These data suggest that short-term consumption of low fat milk in the context of a prudent NCEP diet has no favorable nor deleterious effect on cardiometabolic risk factors associated with MetS in postmenopausal women with abdominal obesity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1475-2891-14-12) contains supplementary material, which is available to authorized users. BioMed Central 2015-01-21 /pmc/articles/PMC4328687/ /pubmed/25604722 http://dx.doi.org/10.1186/1475-2891-14-12 Text en © Drouin-Chartier et al.; licensee BioMed Central. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Drouin-Chartier, Jean-Philippe Gagnon, Josée Labonté, Marie-Ève Desroches, Sophie Charest, Amélie Grenier, Geneviève Dodin, Sylvie Lemieux, Simone Couture, Patrick Lamarche, Benoît Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity |
title | Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity |
title_full | Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity |
title_fullStr | Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity |
title_full_unstemmed | Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity |
title_short | Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity |
title_sort | impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328687/ https://www.ncbi.nlm.nih.gov/pubmed/25604722 http://dx.doi.org/10.1186/1475-2891-14-12 |
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