Hop/Sti1 phosphorylation inhibits its co-chaperone function

In eukaryotes, the molecular chaperones Hsp90 and Hsp70 are connected via the co-chaperone Sti1/Hop, which allows transfer of clients. Here, we show that the basic functions of yeast Sti1 and human Hop are conserved. These include the simultaneous binding of Hsp90 and Hsp70, the inhibition of the AT...

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Detalles Bibliográficos
Autores principales: Röhl, Alina, Tippel, Franziska, Bender, Evelyn, Schmid, Andreas B, Richter, Klaus, Madl, Tobias, Buchner, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328751/
https://www.ncbi.nlm.nih.gov/pubmed/25504578
http://dx.doi.org/10.15252/embr.201439198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328751/
https://www.ncbi.nlm.nih.gov/pubmed/25504578
http://dx.doi.org/10.15252/embr.201439198

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